Results 61 to 70 of about 3,964,337 (291)
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
, 2013 We have created a digital spectral library, using low resolution optical spectra, of photometric and spectral standard stars. The data were acquired using the Cassegrain Spectrograph installed on the 1.9m Radcliffe telescope at the South African ...
James, David
core +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Library Cartoons: A Literature Review of Library-themed Cartoons, Caricatures, and Comics [PDF]
, 2013 To understand differing views of past events, historians, political science scholars, and sociologists have analyzed political and editorial cartoons with themes ranging from elections to fiscal policy to human rights.
Chambers, Julia B.
core +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Science fiction at the Science Library, University of Oslo:
Fafnir, 2017 The University of Oslo Science Library holds a large collection of SF literature. The collection is only 5 years old, but has a rapid growth due to donations. This article describes why the Science Library as an academic institution needs a collection of
Line Nybakk Akerholt, Tone Charlotte Gadmar, and Kyrre Traavik Låberg
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Об объекте библиотековедения (полемические заметки)
Библиосфера, 2012 The author describes the history of understanding of the library science object, its modern conceptions and supposes that some of them draw the librarianship back to the beginning of the XX century.
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