Results 61 to 70 of about 48,040,585 (316)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Kaufman Library Faculty/Staff Newsletter, Fall 2016

, 2016
Fall 2016 issue of the Georgia Gwinnett College Daniel J. Kaufman Library & Learning Center newsletter for faculty and staff. 7 pages. Contents: "Library Dedication", "Quiet Reading Room Exhibit", "Research Services and the Information Literacy Omnibus",
Kaufman Library, GGC Library
core  

Science fiction at the Science Library, University of Oslo

Fafnir, 2017
The University of Oslo Science Library holds a large collection of SF literature. The collection is only 5 years old, but has a rapid growth due to donations.
Line Nybakk Akerholt, Tone Charlotte Gadmar, Kyrre Traavik Låberg   +2 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Documentation, information science, and library science in the U.S.A. [PDF]

Information Processing & Management, 1996
Abstract Three related questions are addressed: why was the work of the European documentalists largely ignored in the U.S.A. before the Second World War? What was the “information science vs library science” argument about? Technological innovation was a vital force in library science in the late 19th century and again after 1950.
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Об объекте библиотековедения (полемические заметки)

Библиосфера, 2012
The author describes the history of understanding of the library science object, its modern conceptions and supposes that some of them draw the librarianship back to the beginning of the XX century.

doaj  

E-science and biomedical libraries

Journal of the Medical Library Association : JMLA, 2009
For a few years now, segments of the research library community have been carefully tracking the emergence of e-science and exploring its implications for the future of research libraries. During 2007–2008, I had the opportunity to work with the Association of Research Libraries (ARL) and a task force looking at issues in e-science and library support ...
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Educational Methodical and Technological Knowledge in Library and Information Activities

Библиосфера
Digital and sociocultural transformations have influenced changes in the content of library activities and the expansion of its boundaries. The emergence of new methods and forms of working with information and library users, the development of new ...
I. S. Pilko
doaj   +1 more source