Results 111 to 120 of about 1,205,678 (309)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

MOBILE APPS OF LIBRARIES: BOON FOR LIBRARY USERS

open access: yes, 2022
Abstract The research paper attempts to describe the importance and adoption of introduction of mobile apps in the context of the library resources and services. As it is evident from the studies that, customized developed mobile apps will play a pivotal role in reaching out to library users in more effective way.
openaire   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Integrating Circulated Technology into the Library Collection Development Plan [PDF]

open access: yes, 2018
Academic libraries are increasingly focused on the acquisition and expansion of circulating technology collections. These collections are often governed by auxiliary library services such as Access Services or IT departments and not considered as part of
Ordinario, Neil
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Artificial Intelligence in Higher Education Institutions Libraries: Analyzing User Perceptions and Expectations

open access: yesOpen Information Science
This study investigates student perceptions of artificial intelligence (AI) adoption in university libraries, focusing on their understanding of AI’s benefits and ethical considerations essential for broader institutional implementation.
Kumar Rajender
doaj   +1 more source

IFLA statement on privacy in the library environment [PDF]

open access: yes
Introduction The rapid advancement of technology has resulted in increasing privacy implications for library and information services, their users, and society.
International Federation of Library Associations and Institutions
core  

CLP LYNCS: Bringing a Library to the Pittsburgh Public Market [PDF]

open access: yes, 2012
Libraries are evolving and always thinking of new and creative ways to reach customers. The Carnegie Library of Pittsburgh devised a new initiative called the Library in Your Neighborhood, Community and School (LYNCS), and its first product was a new ...
Branning, Megan   +2 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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