Results 51 to 60 of about 3,344,473 (262)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Complications in discourses on near-death experiences [PDF]
نشریه پژوهشهای زبانشناسیThe purpose of this article is to find complications in Farsi discourse of Near-Death Experiences (NDE). We first examined the main categories of complications and then compared them in the stories of those who claimed to have near-death experience and ...
Shima Solati, Ali Izanloo, Azam Estaji
doaj +1 more source
P300 as a correlate of false beliefs and false statements
Brain and Behavior, 2023 Introduction This study investigates P300 as a component for false belief and false statement processing with and without a communicative context. The purpose is to understand why P300 has been shown to be commonly involved in false belief and lie ...
Yang Wang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Jurisprudential analysis of the mafia game; Emphasizing the elements of lies, deception and the nature of play [PDF]
پژوهشهای فقهی مسائل مستحدثهMafia game; Emerging and pervasive entertainment among Muslim youth. Since in this game, the approach of the mafia members is to lie and deceive the citizens of the game, the jurisprudential evidence of banning falsehood (lying as a joke) has attracted ...
mohamad hasanzadeh
doaj +1 more source
The pointwise convergence of Fourier Series (I). On a conjecture of Konyagin [PDF]
, 2016 We provide a near-complete classification of the Lorentz spaces $\Lambda_{\varphi}$ for which the sequence $\{S_{n}\}_{n\in \mathbb{N}}$ of partial Fourier sums is almost everywhere convergent along lacunary subsequences. Moreover, under mild assumptions
Lie, Victor
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