Results 41 to 50 of about 299,152 (273)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Classification of derivation algebras in low dimensions

open access: yesArab Journal of Mathematical Sciences, 2018
A left-symmetric algebra A is said to be a derivation algebra if all its left and right multiplications are derivations of the Lie algebra associated to A.
Mohammed Guediri, Kholoud Albalawi
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the derivations of cyclic Leibniz algebras

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2022
Let $L$ be an algebra over a field $F$. Then $L$ is called a left Leibniz algebra, if its multiplication operation $[-,-]$ additionally satisfies the so-called left Leibniz identity: $[[a,b],c]=[a,[b,c]]-[b,[a,c]]$ for all elements $a,b,c\in L$. A linear
M.M. Semko, L.V. Skaskiv, O.A. Yarovaya
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

3-Lie Superalgebras Induced by Lie Superalgebras

open access: yesAxioms, 2019
We show that given a Lie superalgebra and an element of its dual space, one can construct the 3-Lie superalgebra. We apply this approach to Lie superalgebra of ( m , n ) -block matrices taking a supertrace of a matrix as the element of dual space.
Viktor Abramov
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

On Inner Derivations of Leibniz Algebras

open access: yesMathematics
Leibniz algebras are generalizations of Lie algebras. Similar to Lie algebras, inner derivations play a crucial role in characterizing complete Leibniz algebras.
Sutida Patlertsin   +2 more
doaj   +1 more source

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