Results 51 to 60 of about 14,741 (268)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Characterization of Nonlinear Mixed Bi-Skew Lie Triple Derivations on ∗-Algebras
MathematicsThis paper concentrates on examining the characterization of nonlinear mixed bi-skew Lie triple ∗- derivations within an ∗-algebra denoted by A which contains a nontrivial projection with a unit I.
Turki Alsuraiheed +2 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Lie Derivations on Generalized Matrix Algebras by Local Actions
AxiomsLet G=G(A,B,M,N) be a generalized matrix algebra. A linear map Δ:G→G is called a Lie derivation at E∈G if Δ([U,V])=[Δ(U),V]+[U,Δ(V)] for all pairs U,V∈G such that UV=E.
Jinhong Zhuang, Yanping Chen, Yijia Tan
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Differential Operators and Differential Calculus on $delta-$Hom-Jordan-Lie Superalgebras
پژوهشهای ریاضی, 2020 Introduction Hom-algebraic structures appeared first as a generalization of Lie algebras in [1,3], where the authors studied q-deformations of Witt and Virasoro algebras. A general study and construction of Hom-Lie algebras
Valiollah Khalili
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
On functional identities involving n-derivations in rings [PDF]
Journal of Mahani Mathematical ResearchIn this paper, we explore various properties associated with the traces of permuting $n$-derivations satisfying certain functional identities that operate on a Lie ideal within prime and semiprime rings.
Vaishali Varshney +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source