Results 51 to 60 of about 274,463 (263)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Minimal Matrix Representations of Decomposable Lie Algebras of Dimension Less Than or Equal to Five

Extracta Mathematicae, 2018
We obtain minimal dimension matrix representations for each decomposable five-dimensional Lie algebra over R and justify in each case that they are minimal.
Ryad Ghanam, Manoj Lamichhane, Gerard Thompson   +2 more
doaj  

Splittable Lie Groups and Lie Algebras

Journal of Algebra, 2000
Let us call a finite-dimensional Lie algebra \(\mathfrak g\) over a field of characteristic zero Malcev splittable if \(\operatorname {ad}{\mathfrak g}\) is splittable in the sense that for each element of \(\operatorname {ad}{\mathfrak g}\) the semisimple and nilpotent Jordan component belong to \(\operatorname {ad}{\mathfrak g}\).
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reduction of Dynamics with Lie Group Analysis

Advances in Mathematical Physics, 2012
This paper is mainly a review concerning singular perturbation methods by means of Lie group analysis which has been presented by the author. We make use of a particular type of approximate Lie symmetries in those methods in order to construct reduced ...
M. Iwasa
doaj   +1 more source

Controllability of affine right-invariant systems on solvable Lie groups [PDF]

Discrete Mathematics & Theoretical Computer Science, 1997
The aim of this paper is to present some recent results on controllability of right-invariant systems on Lie groups. From the Lie-theoretical point of view, we study conditions under which subsemigroups generated by half-planes in the Lie algebra of a ...
Yuri L. Sachkov
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Reduction of Symplectic Lie Algebroids by a Lie Subalgebroid and a Symmetry Lie Group

Symmetry, Integrability and Geometry: Methods and Applications, 2007
We describe the reduction procedure for a symplectic Lie algebroid by a Lie subalgebroid and a symmetry Lie group. Moreover, given an invariant Hamiltonian function we obtain the corresponding reduced Hamiltonian dynamics. Several examples illustrate the
David Iglesias, Juan Carlos Marrero, David Martín de Diego, Eduardo Martínez, Edith Padrón   +4 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A modification of Hardy-Littlewood maximal function on Lie groups [PDF]

AUT Journal of Mathematics and Computing
For a real-valued function $f$ on a metric measure space $(X,d,\mu)$ the Hardy-Littlewood centered-ball maximal-function of $f$ is given by the `supremum-norm':$$Mf(x):=\sup_{r>0}\frac{1}{\mu(\mathcal{B}_{x,r})}\int_{\mathcal{B}_{x,r}}|f|d\mu.$$In this ...
Maysam Maysami Sadr
doaj   +1 more source