Results 71 to 80 of about 277,829 (311)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

On Lie Semi-Groups [PDF]

Canadian Journal of Mathematics, 1960
Suppose we have a semi-group structure defined ona subset of real Euclidean n-space, En, by (p, q) → F (p, q) = poq. In this note we shall be concerned with a representation T(.) of π as a semi-group of bounded linear operators on a Banach space 𝒳. More particularly, we suppose that postulates P1, P2, P3, P5 and P6 of chapter 25 of (2) are satisfied so
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Explicit Parameterizations of Ortho-Symplectic Matrices in $\mathbb{R}$⁴

Mathematics
Starting from the very first principles we derive explicit parameterizations of the ortho-symplectic matrices in the real four-dimensional Euclidean space.
Clementina D. Mladenova, Ivaïlo M. Mladenov   +1 more
doaj   +1 more source

Stability problems and numerical integration on the Lie group SO(3) × R3 × R3

Open Mathematics, 2018
The paper is dealing with stability problems for a nonlinear system on the Lie group SO(3) × R3 × R3. The approximate analytic solutions of the considered system via Optimal Homotopy Asymptotic Method are presented, too.
Pop Camelia, Ene Remus-Daniel
doaj   +1 more source

Institutional Policies on Artificial Intelligence in Higher Education: Frameworks and Best Practices for Faculty

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article explores institutional policies on artificial intelligence (AI) in higher education. As AI tools become increasingly utilized in academia—from research and teaching to assessment and student support—institutions face growing pressure to establish clear, ethical, and practical guidelines to help guide faculty.
Lauren Azevedo, Pedro Robles, Eric Best, Daniel J. Mallinson   +3 more
wiley   +1 more source

A class of 3-dimensional almost Kenmotsu manifolds with harmonic curvature tensors

Open Mathematics, 2016
Let M3 be a three-dimensional almost Kenmotsu manifold satisfying ▽ξh = 0. In this paper, we prove that the curvature tensor of M3 is harmonic if and only if M3 is locally isometric to either the hyperbolic space ℍ3(-1) or the Riemannian product ℍ2(−4) ×
Wang Yaning
doaj   +1 more source

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi, Marie A. Engh, Tamás Kói, Zsolt Molnár, Gábor Csukly, Klaudia Horváth, Emma Hargitai, Péter Hegyi, Zsolt Mezei   +8 more
wiley   +1 more source

Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu, Yongsheng Wu, Junyu Qu, Rui Zhu, Wenwen Xu, Jiaxiang Xin, Dawei Wang   +6 more
wiley   +1 more source