Results 31 to 40 of about 229,491 (314)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Lie Group Methods in Blind Signal Processing
Sensors, 2020 This paper deals with the use of Lie group methods to solve optimization problems in blind signal processing (BSP), including Independent Component Analysis (ICA) and Independent Subspace Analysis (ISA). The paper presents the theoretical fundamentals of
Dariusz Mika, Jerzy Jozwik
doaj +1 more source
International Mathematics Research Notices, 2008 Presentations of smooth symmetry groups of differentiable stacks are studied within the framework of the weak 2-category of Lie groupoids, smooth principal bibundles, and smooth biequivariant maps. It is shown that principality of bibundles is a categorical property which is sufficient and necessary for the existence of products.
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Homogeneous Triebel-Lizorkin Spaces on Stratified Lie Groups
Journal of Function Spaces and Applications, 2013 Homogeneous Triebel-Lizorkin spaces with full range of parameters are introduced on stratified Lie groups in terms of Littlewood-Paley-type decomposition.
Guorong Hu
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Abstract Lie groups and locally compact topological groups
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2004 We introduce a notion of abstract Lie group by means of the mapping which plays the role of the evolution operator. We show some basic properties of such groups very similar to the fundamentals of the infinite dimensional Lie theory.
Jacek Lech, Tomasz Rybicki
doaj