Results 41 to 50 of about 226,577 (268)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Abstract Lie groups and locally compact topological groups

Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2004
We introduce a notion of abstract Lie group by means of the mapping which plays the role of the evolution operator. We show some basic properties of such groups very similar to the fundamentals of the infinite dimensional Lie theory.
Jacek Lech, Tomasz Rybicki
doaj  

Splittable Lie Groups and Lie Algebras

Journal of Algebra, 2000
Let us call a finite-dimensional Lie algebra \(\mathfrak g\) over a field of characteristic zero Malcev splittable if \(\operatorname {ad}{\mathfrak g}\) is splittable in the sense that for each element of \(\operatorname {ad}{\mathfrak g}\) the semisimple and nilpotent Jordan component belong to \(\operatorname {ad}{\mathfrak g}\).
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Compact Lie Groups, Generalised Euler Angles, and Applications

Universe, 2022
This is mainly a review of an intense 15-year long collaboration between the authors on explicit realisations of compact Lie groups and their applications.
Sergio Luigi Cacciatori, Antonio Scotti
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Double Schubert polynomials for the classical Lie groups [PDF]

Discrete Mathematics & Theoretical Computer Science, 2008
For each infinite series of the classical Lie groups of type $B$, $C$ or $D$, we introduce a family of polynomials parametrized by the elements of the corresponding Weyl group of infinite rank.
Takeshi Ikeda, Leonardo Mihalcea, Hiroshi Naruse   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Linear Hamiltonian Vector Fields on Lie Groups

Mathematics
Linear vector fields on Lie groups constitute a fundamental class of dynamical systems, as their flows are one-parameter subgroups of automorphisms and their infinitesimal behavior is entirely determined by derivations of the Lie algebra.
Víctor Ayala, María Luisa Torreblanca Todco   +1 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source