Results 51 to 60 of about 226,577 (268)

From homogeneous metric spaces to Lie groups

Comptes Rendus. Mathématique
We study homogeneous metric spaces, by which we mean connected, locally compact metric spaces whose isometry group acts transitively.After a review of a number of classical results, we use the Gleason–Iwasawa–Montgomery–Yamabe–Zippin structure theory to ...
Cowling, Michael G., Kivioja, Ville, Le Donne, Enrico, Nicolussi Golo, Sebastiano, Ottazzi, Alessandro   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Contact Semi-Riemannian Structures in CR Geometry: Some Aspects

Axioms, 2019
There is one-to-one correspondence between contact semi-Riemannian structures ( η , ξ , φ , g ) and non-degenerate almost CR structures ( H , ϑ , J ) .
Domenico Perrone
doaj   +1 more source

On Lie Semi-Groups [PDF]

Canadian Journal of Mathematics, 1960
Suppose we have a semi-group structure defined ona subset of real Euclidean n-space, En, by (p, q) → F (p, q) = poq. In this note we shall be concerned with a representation T(.) of π as a semi-group of bounded linear operators on a Banach space 𝒳. More particularly, we suppose that postulates P1, P2, P3, P5 and P6 of chapter 25 of (2) are satisfied so
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Quantum Field Tensor Model of Telecommunication Network Objects Interaction Based on Lie Groups

Proceedings of the International Conference on Applied Innovations in IT
This research explores the application of quantum physics methodologies to analyse digital flows within telecommunication networks. This study introduces a novel tensor model, grounded in the SU(2) Lie group, designed to simulate symmetric and asymmetric
Victor Tikhonov, Yevhen Vasiliu, Eduard Siemens, Oksana Vasylenko, Olena Tykhonova, Kateryna Shulakova, Olexandr Demchenko   +6 more
doaj   +1 more source

Iterative calculus on tangent floors

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2016
Tangent fibrations generate a “multi-floored tower”, while raising from one of its floors to the next one, one practically reiterates the previously performed actions. In this way, the "tower" admits a ladder-shaped structure. Raising to the first floors
Balan Vladimir, Rahula Maido, Voicu Nicoleta   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source