Results 121 to 130 of about 7,823,781 (217)
Frontiers in MedicineBackgroundChronic kidney disease (CKD) is a growing global health burden, closely linked to metabolic and cardiovascular risk factors. Life’s Crucial 9 (LC9) is a novel health assessment tool that expands upon Life’s Essential 8 (LE8) by incorporating ...
Shiyuan Qin +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
MaturitasThis study examines the associations of scores on the Life's Essential 8 (LE8) and Life's Crucial 9 (LC9) scales with all-cause and cardiovascular mortality among postmenopausal women in the United States.We analyzed data from 5499 postmenopausal women aged ≥20 years from the 2005-2014 National Health and Nutrition Examination Survey (NHANES), linked ...
Jun, Wei, Ye, Xu, Yang, Liu
openaire +2 more sources
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Dialecto literario. -- Worcestershire. -- Pertenece a la colección LD 1800-1950 del Salamanca Corpus. -- Mrs. Henry Wood, 1814-1887. -- Ellen Price, 1814-1887. -- A Life's Secret, Vol 2.
Wood, Mrs. Henry, 1814-1887 +1 more
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BMC CancerBackground Life’s Crucial 9 (LC9) is a recently proposed cardiovascular health (CVH) scoring system that integrates psychological well-being with Life’s Essential 8 (LE8). However, its prognostic value remains unclear.
Hongyang Gong, Ming Gao, Zhiwen Zeng
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Life's a Funny Proposition After All
, 1904 First Line: Did you ever sit and ponder, sit and wonder, sit and thinkFirst Line of Chorus: Life's a very funny proposition after allTitle of Larger Work: Little Johnny JonesKey: F ...
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