Results 201 to 210 of about 7,823,781 (217)

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.
Francesco Fortunato, Alessia Giugno, Miriam Sturniolo, Enrico Fratto, Pio Zoleo, Francesca Felicia Operto, Ilaria Sammarra, Antonio Gambardella   +7 more
wiley   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

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The Association of Life’s Crucial 9, Socioeconomic Status, and Social Isolation With Dementia

The American Journal of Geriatric Psychiatry
To investigate the association between Life's Crucial 9 (LC9) and dementia, and the mediating and interaction effects of socioeconomic status or social isolation with LC9, as well as their joint association on dementia.LC9 included diet, physical activity, body mass index, sleep duration, tobacco exposure, blood lipids, blood pressure, blood glucose ...
Jiao-Jiao, Ren, Shu-Fei, Wu, Wen-Fang, Zhong, Jian, Gao, Wei-Qi, Song, Chen, Mao   +5 more
openaire   +2 more sources

Aortic stenosis risk and Life’s Crucial 9: the role of proteomics and inflammation

European Journal of Preventive Cardiology
Abstract Aims This study aims to investigate the association between Life’s Crucial 9 (LC9) and the risk of aortic stenosis and the mediating roles of plasma proteomics and inflammatory biomarkers. Methods and results
Hao Xiang, Yiwei Zhang, Yuanyuan Zhang, Ziliang Ye, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Yu Huang, Yiting Wu, Xianhui Qin   +9 more
openaire   +2 more sources

Life's Crucial 9 and its influence on frailty and survival in patients with cancer: Insights from NHANES

Journal of Geriatric Oncology
This study aims to examine the effect of Life's Crucial 9 (LC9), a comprehensive health measure, on frailty status and its association with all-cause, cancer-related, and non-cancer-related mortality in patients with cancer.A prospective cohort study was conducted with 2466 patients with cancer aged 20 years or older (weighted population: 16,222,181 ...
Zheling, Chen, Xiuxiu, Qiu, Qi, Gao
openaire   +2 more sources

Association of Life's Crucial 9 score with mortality among adults with arthritis: A prospective cohort analysis

Public Health
Cardiovascular diseases (CVD) are the predominant cause of death in arthritis patients. For Life's Crucial 9 (LC9), a newly proposed cardiovascular health metric, its association with mortality in the arthritis population and its prognostic value compared to the conventional Life's Simple 7 (LS7) and Life's Essential 8 (LE8) remain unclear.This is a ...
Xiao-Mei, Huang, Yao-Wei, Zou, Jie, Lu, Kui-Min, Yang, Pei-Wen, Jia, Ying, Yang, Qiu-Hua, Chen, Zhi-Ming, Ouyang   +7 more
openaire   +2 more sources

Mediation analysis of adiposity and inflammation in the associations of Life’s Crucial 9 and Life’s Essential 8 with mortality among postmenopausal women

Menopause
Objective: Life’s Essential 8 (LE8) and Life’s Crucial 9 (LC9) summarize overall cardiovascular health. This study investigated the associations between LC9 and LE8 with all-cause and cardiovascular mortality in postmenopausal women and further assessed whether adiposity-related and inflammation-related ...
Jun, Wei, Yang, Liu
openaire   +2 more sources