Results 71 to 80 of about 10,179,200 (235)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Life's Simple 7 and Global- and Domain-Specific Cognitive Function in an Older Adult Population

, 2021
The American Heart Association Life's Simple 7 (LS7), a metric that classifies cardiovascular health using modifiable risk factors, has been reported to be associated with cognitive function.
Lopez, Kyra Elise
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Life's Simple 7 and Peripheral Artery Disease Risk: The Atherosclerosis Risk in Communities Study [PDF]

American Journal of Preventive Medicine, 2018
The American Heart Association's Life's Simple 7 includes seven metrics of ideal cardiovascular health to target for cardiovascular disease prevention. This study determined the relationship between Life's Simple 7 and incident peripheral artery disease in a biracial cohort of middle- and older-aged adults.This analysis included 12,865 participants ...
Parveen K. Garg, Wesley T. O'Neal, Yejin Mok, Gerardo Heiss, Joseph Coresh, Kunihiro Matsushita   +5 more
openaire   +2 more sources

Work‐Related Stress Is Associated With Unfavorable Cardiovascular Health: The Multi‐Ethnic Study of Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Work‐related stress is a psychosocial risk factor linked to a higher risk of cardiovascular disease. However, the association between work‐related stress and cardiovascular health (CVH) is not well established.
Oluseye Ogunmoroti, Olatokunbo Osibogun, Norrina B. Allen, Victor Okunrintemi, Yvonne Commodore‐Mensah, Amit J. Shah, Erin D. Michos   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Impact of Life's Simple 7 on the incidence of major cardiovascular events in high-risk Spanish adults in the PREDIMED study cohort

, 2019
Introduction and objectives: The Life's Simple 7 strategy of the American Heart Association proposes 7 metrics of ideal cardiovascular health: body mass index (BMI) < 25 mg/m2, not smoking, healthy diet, moderate physical activity ≥ 150 min/wk, total ...
Toledo, Estefanía, Alonso-Gómez, A., Serra-Majem, L., Gómez-Gracia, Enrique, Basora, J., Babio, N., Estruch, Ramón, Fiol, Miquel, Fitó, Montserrat, Martínez-González, Miguel, Lapetra, José, Pintó, Xavier, Muñoz, Miguel A., Ros, Emilio, Sorlí, José V., Corella, Dolores, Buil-Cosiales, P., Díez-Espino, Javier   +17 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study [PDF]

Nutrients, 2019
Background: Among African Americans (AAs), attaining higher levels of American Heart Association (AHA) ideal cardiovascular health (Life’s Simple 7 [LS7]) is associated with lower risk of diabetes and cardiovascular disease (CVD). We previously showed that aldosterone is associated with higher risk of diabetes and CVD in AAs.
Veena Kesireddy, Yubo Tan, David Kline, Guy Brock, James B. Odei, Bjorn Kluwe, Valery S. Effoe, Justin B. Echouffo Tcheugui, Rita R. Kalyani, Mario Sims, Herman A. Taylor, Morgana Mongraw-Chaffin, Ehimare Akhabue, Joshua J. Joseph   +13 more
openaire   +2 more sources

Modifiable risk factors and metabolic health in risk of cardiovascular disease among US adults: A nationwide cross-sectional study

International Journal of Cardiology. Cardiovascular Risk and Prevention
Background: Metabolic syndrome (MetS) could increase the risk of cardiovascular disease (CVD) by 2-fold. Ideal control of modifiable risk factors in Life's Simple 7 (LS7) could reduce the CVD risk among the general population.
Ruihuan Shen, Xuantong Guo, Tong Zou, Lihong Ma   +3 more
doaj   +1 more source