Results 121 to 130 of about 10,012,980 (241)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Application of machine learning algorithms in osteoporosis analysis based on cardiovascular health assessed by life’s essential 8: a cross-sectional study

Journal of Health, Population and Nutrition
Background Life’s Essential 8 (LE8) for assessing cardiovascular health (CVH) has been demonstrated to be inversely associated with osteoporosis (OP).
Haolin Shi, Yangyi Fang, Xiuhua Ma
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Associations of street-view greenspace exposure with cardiovascular health (Life’s Essential 8) among women in midlife

Plain English summary Many women experience suboptimal cardiovascular health during midlife, increasing their risk of heart disease. Research suggests that exposure to greenspace, such as vegetation and trees, may benefit heart health, but most studies ...
Chavarro, Jorge E., Lin, Pi-I Debby, Esra Suel, Suel, Esra; https://orcid.org/, James, Peter, Marie-France Hivert, Oken, Emily, Sheryl L. Rifas-Shiman, Hivert, Marie-France, Rifas-Shiman, Sheryl, Li Yi, Izzuddin M. Aris, Jorge E. Chavarro, Pi-I Debby Lin, Emily Oken, Yi, Li, Aris, Izzuddin M., Peter James   +17 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Association of life’s essential 8 and inflammatory biomarkers with nutritional anemia in UK adults

Several modifiable health factors in Life’s Essential 8 (LE8) are linked to nutritional anemia and can assess overall cardiovascular health (CVH).
Dongfeng Zhang, Guozheng Wang, Weijing Wang, Jingjing Wang, Xueting Qi   +4 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Life’s Essential 8 and Genetic Susceptibility in Early- and Late-Onset Atrial Fibrillation: A Prospective Study

Background Global early-onset atrial fibrillation (AF) is surging, yet the distinct determinants of early- versus late-onset AF remain poorly understood.
Lei Ding, Hongda Zhang, Chao Liu, Yu Jiang, Min Tang, Zhuoxi Feng, Zihao Wu   +6 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Association between life’s essential 8 and bone mineral density among adults aged 20–59 years

This study investigates the relationship between Life’s Essential 8 (LE8) scores and bone mineral density (BMD) in adults aged 20–59 years. This cross-sectional analysis employed nationally representative data from NHANES 2011–2018.
Peiwei Wu, Yuyu Cui, Xiaoyan Zhou, Zhaoshu Cui, Yuanyuan Guo, Zhening Xu   +5 more
core   +1 more source