Results 71 to 80 of about 10,012,980 (241)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Galectin-3 in Cardiovascular Health: A Narrative Review Based on the Life’s Essential 8 and Life’s Simple 7 Frameworks

This project is a narrative review exploring the role of galectin-3 (Gal-3) in cardiovascular health and disease, structured according to the American Heart Association's Life’s Essential 8 and Life’s Simple 7 frameworks.
Adrian Martuszewski, Rafał Poręba, Patrycja Paluszkiewicz, Paweł Gać   +3 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Life’s crucial 9 is inversely and linearly associated with female infertility prevalence: a cross-sectional analysis from NHANES 2013–2018

Scientific Reports
Cardiovascular health (CVH) and depression may be associated with female infertility. More recently, it has been suggested that the addition of psychological health assessment to Life’s Essential 8 (LE8), known as Life’s Crucial 9 (LC9), may be ...
Bianfang Li, Han Zhai
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Additional file 1 of The influence of Life’s Essential 8 on the link between socioeconomic status and depression in adults: a mediation analysis

Additional file 1: Supplementary Figure S1. Missing data of included participants. Supplementary Figure S2. (A) AIC, BIC, and (B) G2 in models with different numbers oflatent classes in NHANES. Supplementary Figure S3.
Changjun Gao (11711223), Yongfei Liu (713467), Xude Sun (8749944), Jiangjing Li (14764921), Heming Zhang (7900445), Lin Zhang (8926), Hongxia Xiang (663768)   +6 more
core   +1 more source

Chronotype, Life's Essential 8, and Risk of Cardiovascular Disease: A Prospective Cohort Study in UK Biobank. [PDF]

J Am Heart Assoc
Introduction: Individuals with an evening chronotype often experience circadian misalignment, which may disrupt health behaviors and circadian regulation of cardiometabolic functions. However, the associations of chronotype with modifiable cardiovascular
Kianersi S, Potts KS, Wang H, Sofer T, Noordam R, Rutter MK, Rexrode K, Redline S, Huang T.   +8 more
europepmc   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Composite cardiovascular health indices (Life’s essential 8 and Life’s crucial 9) and female infertility: an NHANES 2013–2018 cross−sectional analysis [PDF]

BackgroundFemale infertility affects 10–15% of couples worldwide and is influenced by multiple factors, including cardiovascular and metabolic health. This study examines the association between composite cardiovascular health indices—Life’s Essential 8 (
Yanping Gao, Yukun Duan, Hui Li, Peixiu Liu   +3 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source