Results 91 to 100 of about 692,170 (234)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Now we must cross a sea: remarks on transformational leadership and the Civil Rights Movement [PDF]
, 2015 Published ...
Fluker, Walter
core
Evolution and the Second Law of Thermodynamics: Effectively Communicating to Non-Technicians [PDF]
, 2010 Given the degree of disbelief in the theory of evolution by the wider public, scientists need to develop a collection of clear explanations and metaphors that demonstrate the working of the theory and the flaws in antievolutionist arguments.
Gimbel, Steven, Schreiber, Alexander
core +2 more sources
Arteriosclerosis, Thrombosis and Vascular Biology, 2019 Objective— We examined the association of cardiovascular health (CVH) metrics with the development and progression of coronary artery calcium (CAC) among apparently healthy adults.
Seolhye Kim +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Meaning in Life and the Metaphysics of Value [PDF]
, 2017 According to subjectivist views about a meaningful life, one's life is meaningful in virtue of desire satisfaction or feelings of fulfilment. Standard counterexamples consist of satisfaction found through trivial or immoral tasks.
Evers, Daan
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
An Objective Bayesian Analysis of Life's Early Start and Our Late Arrival
, 2020 Life emerged on the Earth within the first quintile of its habitable window, but a technological civilization did not blossom until its last. Efforts to infer the rate of abiogenesis, based on its early emergence, are frustrated by the selection effect ...
Kipping, David
core