Results 121 to 130 of about 692,170 (234)

Magnetism, FeS colloids, and Origins of Life

, 2010
A number of features of living systems: reversible interactions and weak bonds underlying motor-dynamics; gel-sol transitions; cellular connected fractal organization; asymmetry in interactions and organization; quantum coherent phenomena; to name some ...
A Ahniyaz, A Engel, A Etxeberria, A Nagya, A Preisinger, A Pross, A Yethiraj, AD Patel, AD Patel, AD Patel, AG Cairns-Smith, AJ Boyce, AJ Boyce, AL Buchachenko, AM Selvam, AM Tishin, AP Roberts, AS Keys, AY Zubarev, AY Zubarev, B-O Küppers, BA Grzybowski, C Bustamante, C Huber, C Jaryznski, C Tenailleau, C Viedma, CR Vestal, D Abel, D Abel, D Rickard, D Rickard, D Rickard, den Hollander WThF, DG Drubin, DI Khomskii, DJ Vaughan, DJ Vaughan, DL Stein, DS Kelley, E Schroedinger, EJ Milner-White, EJ Milner-White, ET Degens, EV Koonin, F Heylighen, FJ Dyson, FM Harold, G Mitra-Delmotte, G Nicolis, G Wächtershäuser, GL Früh-Green, GN Ling, GO Arrhenius, GS Engel, H Frohlich, H Frohlich, H Ohfuji, H Ohfuji, H Ohldag, HH Pattee, HH Pattee, HM Palmer, I Adler, I Kant, IK Kominis, J Al-Khalili, J Breivik, J Charnock, J Cheon, J Dyment, J Hemberger, J Higo, J Hoffmeyer, J Li, J McFadden, J Spitzer, J Torbet, JC Weaver, JD Bernal, JK Jain, JL Kirschvink, JL Kirschvink, JL Kirschvink, JM McBride, JP Ferris, JS Ban, JS Beard, JT Trevors, K Hatori, K Matsuno, K Righter, KA Michie, KM Doll, LE Orgel, LE Orgel, LE Orgel, LS Levitov, M Haw, M Jibu, M Mostovoy, M Polyani, M Winkelhofer, M Wolthers, M Wu, MF Chaplin, MF Chaplin, Mitra-Delmotte, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MO Goerbig, MP Pileni, NE Mavromatos, NJ Cerf, P Baaske, P Bak, P Galland, P Wasilewski, PCW Davies, PCW Davies, PCW Davies, PW Anderson, R Hazen, R Kopelman, R Lifshitz, R Palm, R Pastor-Satorras, R Phillips, R Shapiro, R Skomski, RA Dunlap, RCL Larter, RD Astumian, RD Astumian, RE Rosensweig, RT Wilkin, RW Chantrell, S Hagan, S Itoh, S Kauffman, S Lloyd, S Odenbach, S Sun, S Taketomi, S Traverso, SA Newman, T Schroeder, V Fritsch, V Hoffmann, VK Mer La, VM Goldschmidt, VN Manoharan, VTh Marteinsson, VV Korolev, W Cruz da, W Martin, W Martin, WH Zurek, Y Kwon, Y Lalatonne, Y Min, Z Merali, Z Sawlowicz, Z Sawlowicz, Z Wang   +172 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Origin of life in a digital microcosm

, 2017
While all organisms on Earth descend from a common ancestor, there is no consensus on whether the origin of this ancestral self-replicator was a one-off event or whether it was only the final survivor of multiple origins.
Adami, Christoph, G, Nitash C, Hintze, Arend, LaBar, Thomas   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Is Coming into Existence Always a Harm? Qoheleth in Dialogue with David Benatar [PDF]

, 2019
Contemporary philosopher David Benatar has advanced the self-evidently controversial claim that “coming into existence is always a harm.” Benatar’s argument turns on the basic asymmetry between pleasure and pain, an asymmetry he seeks to explain by the ...
Peterson, Jesse
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source