Results 71 to 80 of about 692,170 (234)

From Cosmos to Intelligent Life: The Four Ages of Astrobiology

, 2012
The history of life on Earth and in other potential life-bearing planetary platforms is deeply linked to the history of the universe. Since life as we know it relies on chemical elements forged in dying heavy stars, the universe needs to be old enough ...
Abel, Arrhenius, Bonner, Fenchel, Fitz, Gleiser, Kaltenegger, Lunine, Marcelo Gleiser, Oparin, Prigogine, Salama, Smoot, Susskind, Susskind, Ward, Webb, Weinberg   +17 more
core   +1 more source

Associations of Life’s Simple 7 With Cerebral Small Vessel Disease

Stroke, 2022
Background: The purpose of this study is to examine the associations of Life’s Simple 7 (LS7) with risks of cerebral small vessel disease (CSVD) and its magnetic resonance imaging markers.
Dandan Liu, Xueli Cai, Yingying Yang, Suying Wang, Dongxiao Yao, Lerong Mei, Jing Jing, Shan Li, Hongyi Yan, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang   +14 more
semanticscholar   +1 more source

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

A precision medicine approach to sex-based differences in ideal cardiovascular health

Scientific Reports, 2021
Cardiovascular disease risk factor profiles and health behaviors are known to differ between women and men. Sex-based differences in ideal cardiovascular health were examined in the My Research Legacy study, which collected cardiovascular health and ...
Jane A. Leopold, Elliott M. Antman
doaj   +1 more source

Stress and Achievement of Cardiovascular Health Metrics: The American Heart Association Life's Simple 7 in Blacks of the Jackson Heart Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Ideal cardiovascular health metrics (defined by the American Heart Association Life's Simple 7 [LS7]) are suboptimal among blacks, which results in high risk of cardiovascular disease. We examined the association of multiple stressors with LS7
LaPrincess C. Brewer, Nicole Redmond, J. Slusser, C. Scott, A. Chamberlain, L. Djoussé, C. Patten, V. Roger, M. Sims   +8 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Association between Life’s Simple 7 and Menopause in a Community-based Population

Journal of Medical Sciences
Background: In 2010, the American Heart Association defined a new concept of ideal cardiovascular health (CVH) called Life’s Simple 7, which comprises seven parts, including smoking status (nonsmoking), body mass index (BMI) (
Wen-Chung Lu, Yuan-Ping Chao, Yung-Wen Cheng, Zhe-Yu Yang, Jun-Wei Huang, Tao-Chun Peng   +5 more
doaj   +1 more source

Growth and Decay in Life-Like Cellular Automata

, 2009
We propose a four-way classification of two-dimensional semi-totalistic cellular automata that is different than Wolfram's, based on two questions with yes-or-no answers: do there exist patterns that eventually escape any finite bounding box placed ...
A. Adamatzky, A. Lafusa, D. Eppstein, D. Griffeath, E.R. Berlekamp, H. Chaté, H.V. McIntosh, J. Gravner, J. Gravner, J. Gravner, J.T. Baldwin, K. Culik II, M. Gardner, N.H. Packard, N.M. Gotts, S. Wolfram, S. Wolfram, T. Toffoli, W. Li, W.K. Wootters   +19 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source