Results 121 to 130 of about 20,559,883 (358)

The Anthropological and Social Consequences of the Triadic Logic: A Proposal for Adapting the Logic Model to Life Thinking

open access: yesReligions
Modernity is characterised by a specific scientific paradigm based on binary logic. Neither freedom nor creativity have a place in this logical model. On the contrary, triadic logic enables rational consideration of an anthropological and social model ...
Teresa Aizpun
doaj   +1 more source

Life detection [PDF]

open access: yes, 1969
Compact automated laboratory unit has 60 independently treatable culture chamber assemblies for metabolic studies of cultured microorganisms on the surface of Mars or other ...
Martin, W. H.
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Religious Life [PDF]

open access: yes, 2001
Religious life is a generic term for a variety of forms of Christian life that originated, as a radical response to the gospel, in the rst century and continue to develop in the present, predominantly among Roman *Catholics and *Eastern Orthodox but also,
Schneiders, Sandra Marie
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Sylvia Earle: Ocean Life Makes Human Life Possible [PDF]

open access: yes, 2013
Legendary oceanographer and marine scientist lauds RWU for marine biology and aquaculture programs as a leading example of research and conservation ...
Rodrigues, Jill
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Life satisfaction across life course transitions [PDF]

open access: yes
This paper looks at how life satisfaction changes as we pass through various life transitions on the pathway from adolescence through young adulthood, middle age and into old age.
David de Vaus, Lixia Qu
core  

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