Results 111 to 120 of about 1,079,597 (317)
Evaluation of the concept of pressure proof testing fuselage structures [PDF]
The FAA and NASA have recently completed independent technical evaluations of the concept of pressure proof testing the fuselage of commercial transport airplanes. The results of these evaluations are summarized. The objectives of the evaluations were to
Harris, Charles E., Orringer, Oscar
core +1 more source
Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice [PDF]
, 2016 The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1-/-) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR
Irvine, Elaine E. +5 more
core +2 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effects of age and physical activity on the autonomic control of heart rate in healthy men
Brazilian Journal of Medical and Biological Research, 2005 The effects of the aging process and an active life-style on the autonomic control of heart rate (HR) were investigated in nine young sedentary (YS, 23 ± 2.4 years), 16 young active (YA, 22 ± 2.1 years), 8 older sedentary (OS, 63 ± 2.4 years) and 8 older
R.C. Melo +10 more
doaj +1 more source
Intrinsic aerobic capacity sets a divide for aging and longevity [PDF]
, 2011 <p><b>Rationale:</b> Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease.
Charles F. Burant +17 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Sālmand, 2019 Objectives Like the global population, the Iranian population is aging rapidly. Measures should be taken to maintain aging population healthy and happy.
Mohammad Mohammadi Mehr +3 more
doaj
RESEARCH ON THERMAL AGING OF INDUSTRIAL ROBOT CABLE SHEATH
Jixie qiangdu, 2021 In the long-term work of industrial robot cables,the mechanical properties will be insufficient due to aging,which will affect the normal operation of the robot.
ZHOU ChunLin, WU Can, YANG Kai, NI Jing
doaj
Aging & Mental HealthObjectives: Playfulness describes individual differences in (re)framing situations in a way that they are experienced as interesting, intellectually stimulating, or entertaining. We extended the study of playfulness to groups of middle- and higher age and examined the relations of four facets of playful- ness (Other-directed, Lighthearted, Intellectual,
Kay Brauer +2 more
openaire +3 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source