Results 161 to 170 of about 13,579,615 (311)

Growth Hormone Receptor Antagonism Extends Lifespan. [PDF]

Aging Cell
List EO, Berryman DE, Lach GS, Minto DF, Weese K, Kopchick JJ.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging. [PDF]

Cell Mol Life Sci
Sleiman M, Ranti D, Baskaran S, Kreis P, Muth S, Gallrein C, Münster-Wandowski A, Rahnis N, Cirri E, Eickholt BJ, Kirstein J.   +10 more
europepmc   +1 more source

Study of aging life for EMU arresters based on aging tests and principal component analysis method

On-board lightning arresters are critical components for ensuring the safety of EMUs operating on high-speed railways. This paper focuses on arresters mounted on EMUs as the research object. Through performance and aging tests (thermal-electrical aging, impulse aging, and high-order harmonic aging) conducted on arresters in operation over different ...
LI Ying, SONG Yanjun, XU Yuqi, LIU Kai, CHEN Kui, GAO Guoqiang   +5 more
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cognitive Reserve and Psychological Well-Being in Aging Population of Community-Dwellers in Spain. [PDF]

Brain Behav
Ordin M, Barrasa A, López-Granero C, Polyanskaya L.   +3 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Age-related molecular and functional remodeling of the choroid plexus in the gray mouse lemur. [PDF]

PLoS One
Amiot F, Etchebest A, Andriambelo B, St-Germain J, Avino M, Plourde M, Laurent B, Pifferi F.   +7 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Insights into thermo-oxidative aging properties and mechanisms of high-content desulfurized rubber modified asphalt: A macro-rheological and micro-chemical perspective. [PDF]

PLoS One
Li X, Li C, Xi L, Zhu Y, Dong P, Chen P, Zhang F, Yang F.   +7 more
europepmc   +1 more source