Results 171 to 180 of about 1,079,597 (317)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Wisdom and Life Purpose as Predictors of Mental Well-Being Among Middle-Aged to Older Adults: Cross-Sectional Study. [PDF]

JMIR Ment Health
Arpaci I, Kuşci I, Karataş K, Baloglu M.   +3 more
europepmc   +1 more source

Study of aging life for EMU arresters based on aging tests and principal component analysis method

On-board lightning arresters are critical components for ensuring the safety of EMUs operating on high-speed railways. This paper focuses on arresters mounted on EMUs as the research object. Through performance and aging tests (thermal-electrical aging, impulse aging, and high-order harmonic aging) conducted on arresters in operation over different ...
LI Ying, SONG Yanjun, XU Yuqi, LIU Kai, CHEN Kui, GAO Guoqiang   +5 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles. [PDF]

BMC Immunol
Paniskaki K, Stervbo U, Goretzki S, Hufnagel D, Anft M, Heidecke H, Westhoff TH, Rohn H, Felderhoff-Mueser U, Witzke O, Dohna-Schwake C, Babel N.   +11 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Concurrent associations between objective markers and subjective markers of aging with indicators of successful aging: An integrative approach. [PDF]

Eur J Ageing
Selovin F, de Paula Couto MCP, Scholz M, Baber R, Riedel-Heller SG, Wirkner K, Zeynalova S, Rothermund K.   +7 more
europepmc   +1 more source

Does It Pay to Be Productive? The Case of Age Groups [PDF]

Using longitudinal matched employer-employee data for the period 1999-2006, we investigate the relationship between age, wage and productivity in the Belgian private sector. More precisely, we examine how changes in the proportions of young (16-29 years),
Cataldi, Alessandra, Kampelmann, Stephan, Rycx, Francois   +2 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Could animal models be used to longitudinally track intrinsic capacity during aging? [PDF]

J Nutr Health Aging
Chen IT, Lu WH, Hsiao FY, Chen LK, Parini A, Santin Y, Guiard B, Pradere JP, de Cabo R, Vellas B, Rolland Y, de Souto Barreto P.   +11 more
europepmc   +1 more source