Results 131 to 140 of about 4,110,851 (310)
Digital EngineeringProduction devices often lack interoperability, making it difficult to integrate them into a centralized system. Open Platform Communications Unified Architecture tackles this issue, combining a communication stack with an information modeling approach ...
Robert Knobloch +4 more
doaj +1 more source
Investors\u27 Asset Allocations versus Life-Cycle Funds
, 1999 Life-cycle funds, among the newest asset allocation fund offerings, are managed according to investors\u27 time horizons and risk tolerances. Partly in response to the appearance of these funds, we examined the relationships among the risk in individual ...
Schooley, Diane K., Worden, Debra
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Life cycle wage and job changes [PDF]
Evidence from the Panel Study of Income Dynamics shows that while the majority of job changers who state they were not fired or laid off choose jobs with wages that are higher than their previous jobs, a substantial proportion of these job changers ...
Ed Nosal, Peter Rupert
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Leraning, life-cycle and entrepreneurial investment [PDF]
In this paper, present a calibrated model of life-cycle occupation and investment decisions where households choose between paid work and entrepreneurship and conditional on the latter how much of their savings to invest in their business. The returns to
Claudio Campanale
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Family violence across the life cycle [PDF]
Aims to address clinical questions that general practitioners (GPs) may have in identifying and responding to patients experiencing family violence. Background Family violence covers a range of abuse including child abuse and neglect, intimate partner ...
Elizabeth Hindmarsh +3 more
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