Results 141 to 150 of about 1,623,376 (313)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Oregon Plan for Salmon and Watersheds
, 2006 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.2003/2005-Mode of access: Internet from the Oregon ...
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LIFE CYCLE ANALYSIS (LCA) FOR SUSTAINABLE ARCHITECTURE [PDF]
, 2011 Life Cycle Analysis (LCA), a kind of cradle–to–grave paradigm based instrumentfor measuring the product sustainability by analyzing energy, cost, and environ-mental impacts that would be spent and occur along the product–life–cycle, isone of mechanisms ...
Subadra Abioso, Wanita
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Development of a life cycle cost estimating framework for oil refineries [PDF]
, 2011 This study is concerned with the understanding of some vital features of various life cycle costing methodologies and tools. Integrating these features with the refinery technical processes would assist in the development of a life cycle costing ...
Okafor, Okechukwu Peter
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Life Cycle Model of Consumption and Saving [PDF]
The life-cycle model is the standard framework which economists use to think about the intertemporal allocation of time, money and effort. The model suggests that households should `smooth' expenditures.
Thomas F. Crossley, Martin Browning
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Life cycle assessment of Libyan crude oil
, 2014 Petroleum products such as petrol and diesel are fossil fuels and have a high environmental impact. There is a demand to minimize these impacts especially in the upstream and midstream oil operations, i.e. exploration, production and refining processes,
Irhoma, A, Higginson, M, Su, D
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