Results 121 to 130 of about 4,110,851 (310)
Water Resources ResearchThe accuracy of peak streamflow simulation is often lower than that of normal streamflow simulation, posing a significant challenge. This study introduces stochastic resonance (SR) to enhance simulation accuracy, utilizing its ability to leverage noise ...
Xungui Li +4 more
doaj +1 more source
Health Investment over the Life-Cycle [PDF]
We study the evolution of health investment over the life-cycle by calibrating a model of endogenous health accumulation. The model is able to produce the decline in labor supply with age as well as the hump-shaped consumption profile.
Hao Zhang, Hui He, Timothy J. Halliday
core
Tidal energy machines: A comparative life cycle assessment
, 2013 Marine energy in the UK is currently undergoing a period of exponential growth in terms of development and implementation. The current installed tidal energy capacity of around 4MW is expected to rise to provide up to 20% of the UK’s electricity demand ...
Callaghan J +8 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A Theory of Industry Life Cycle [PDF]
This paper derives the equilibrium timing of entries and exits as well as the equilibrium output levels over the industry life cycle. This paper also examines the effects of the increase in entry costs. It turns out that the first entry may occur earlier
Jinsoo Yoo
core
A Framework for Life Cycle Sustainability Assessment of Road Salt Used in Winter Maintenance Operations [PDF]
, 2016 It is important to assess from a holistic perspective the sustainability of road salt widely used in winter road maintenance (WRM) operations. The importance becomes increasingly apparent in light of competing priorities faced by roadway agencies, the ...
Cui, Na, Shi, Xianming, Xie, Ning
core
Threats Management Throughout the Software Service Life-Cycle
, 2014 Software services are inevitably exposed to a fluctuating threat picture. Unfortunately, not all threats can be handled only with preventive measures during design and development, but also require adaptive mitigations at runtime.
Gjære, Erlend Andreas +1 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source