Results 121 to 130 of about 1,623,376 (313)

Showcasing life cycle management

Industries following a linear approach assume that ‘if they produce more, they will sell more’. As new trends in production and consumption models emerge due to growing social, environmental and economic pressures, the linear approach is being replaced ...
Cano Londoño, Natalia AndreaCA100002212947868020040454410000-0003-4828-6442da2e1992-e388-11ec-a039-aec0cdf8977c, Sonnemann, Guidoeditor, Valdivia, Soniaeditor, Wiche, Pia   +3 more
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Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Environment-oriented Assessments for the Life Cycle Engineering

, 2022
S.264-275The challenges of an ecological Life Cycle Engineering requires the optimization of the processes and products concerned. Environment-oriented assessments are a pre-condition for deriving optimization potentials and design requirements for ...
Friedel, A., Westkämper, E.
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Frailty associated with nutritional status, functionality, physical activity and socioeconomic level, in older adults in Ecuador, post-pandemic

BMC Geriatrics
Background Aging is a complex, multifactorial process in which nutritional alterations, sedentary lifestyle, and chronic diseases can increase the risk of functional limitations, dependence, and disability in older adults.
Lorena Esperanza Encalada-Torres, Sandra Victoria Abril-Ulloa, Silvia Rocío Sempértegui-León   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Three-Dimensional Modeling and Analysis of Directed Energy Deposition Melt Pools Based on Physical Information Neural Networks

Applied Sciences
In Directed Energy Deposition (DED), modeling the molten pool temperature field is crucial for precise temperature control, process optimization, and quality improvement.
Xiang Han, Zhuang Qian, Xinyue Gao, Huaping Li, Zhongqing Peng, Yu Long   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The LIFE project research review: mapping the landscape, riding a life cycle

, 2005
The LIFE project research review investigates both life cycle costing and digital preservation, with a view to creating a useable life cycle costing model that can be applied to digital preservation within an HE/FE environment.
Watson, J.
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