Results 101 to 110 of about 9,341,349 (251)

Numerical Analysis of Crack Path Effects on the Vibration Behaviour of Aluminium Alloy Beams and Its Identification via Artificial Neural Networks

Sensors
Understanding and predicting the behaviour of fatigue cracks are essential for ensuring safety, optimising maintenance strategies, and extending the lifespan of critical components in industries such as aerospace, automotive, civil engineering and energy.
Hilal Doğanay Katı, Jamilu Buhari, Arturo Francese, Feiyang He, Muhammad Khan   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Showcasing life cycle management

Industries following a linear approach assume that ‘if they produce more, they will sell more’. As new trends in production and consumption models emerge due to growing social, environmental and economic pressures, the linear approach is being replaced ...
Cano Londoño, Natalia AndreaCA100002212947868020040454410000-0003-4828-6442da2e1992-e388-11ec-a039-aec0cdf8977c, Sonnemann, Guidoeditor, Valdivia, Soniaeditor, Wiche, Pia   +3 more
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Three-Dimensional Modeling and Analysis of Directed Energy Deposition Melt Pools Based on Physical Information Neural Networks

Applied Sciences
In Directed Energy Deposition (DED), modeling the molten pool temperature field is crucial for precise temperature control, process optimization, and quality improvement.
Xiang Han, Zhuang Qian, Xinyue Gao, Huaping Li, Zhongqing Peng, Yu Long   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Probabilistic Electrostatic Discharge Risk Assessment in High-Reliability Electronics Manufacturing

IEEE Access
Electrostatic discharge (ESD) remains a reliability threat in high-reliability electronics manufacturing despite industry adoption of ESD standards and control programs.
Matthew T. Thomas, Michael G. Pecht
doaj   +1 more source