Results 101 to 110 of about 4,110,851 (310)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Numerical Analysis of Crack Path Effects on the Vibration Behaviour of Aluminium Alloy Beams and Its Identification via Artificial Neural Networks

Sensors
Understanding and predicting the behaviour of fatigue cracks are essential for ensuring safety, optimising maintenance strategies, and extending the lifespan of critical components in industries such as aerospace, automotive, civil engineering and energy.
Hilal Doğanay Katı, Jamilu Buhari, Arturo Francese, Feiyang He, Muhammad Khan   +4 more
doaj   +1 more source

Cocoa farmers' characteristics on climate variability and its effects on climate change adaptation strategy [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Climate change has a greater influence on agriculture through local climate variability than global climate patterns. The impact of climate change on agricultural productivity and shifts in crop patterns varies significantly ...
I. Idawati, N.A. Sasongko, A.D. Santoso, M. Septiani, T. Handayani, A.Y.N. Sakti, B.D. Purnamasari   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Use of UL 1642 Impact Testing for Li-ion Pouch Cells

IEEE Access, 2019
The industry demand for high-capacity cells with a small footprint is a result of demands for improved products and new applications. However, this presents challenges in terms of safety.
Ryan Aalund, Michael Pecht
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Safety Analysis of Lithium-Ion Cylindrical Batteries Using Design and Process Failure Mode and Effect Analysis

Batteries
Cylindrical lithium-ion batteries are widely used in consumer electronics, electric vehicles, and energy storage applications. However, safety risks due to thermal runaway-induced fire and explosions have prompted the need for safety analysis ...
Sahithi Maddipatla, Lingxi Kong, Michael Pecht   +2 more
doaj   +1 more source

Exploring personalized life cycle policies [PDF]

, 2007
Ambient Intelligence imposes many challenges in protecting people's privacy. Storing privacy-sensitive data permanently will inevitably result in privacy violations.
Anciaux, N.L.G., Apers, P.M.G., Fokkinga, M.M., Heerde, H.J.W van   +3 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Knowledge Life Cycle for e-learning

, 2006
In this paper, we examine the semantic aspects of e-learning from both pedagogical and technological points of view. We suggest that if semantics are to fulfil their potential in the learning domain then a paradigm shift in perspective is necessary, from
Davis, Hugh, Doody, Karl, Millard, David, Tao, Feng, Woukeu, Arouna   +4 more
core   +1 more source