Results 91 to 100 of about 1,623,376 (313)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
An Adaptive Online Diagnosis and Prognosis Approach for Digital Circuits
IEEE AccessFailures of digital circuits can cause significant system downtime in industry sectors including manufacturing, telecommunications, transportation, and healthcare.
Huwei Dong +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
, 2022 S.14-25Der Beitrag stellt unterschiedliche Methoden und Ansätze für ein ganzheitliches Life Cycle Management ...
Westkämper, E.
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Life-cycle assessment of buildings: a Review
, 2009 Life-Cycle Assessment (LCA) is one of various management tools for evaluating environmental concerns. This paper reviews LCA from a buildings perspective.
Menzies, Gillian Frances +5 more
core +1 more source
Energy Science & EngineeringThis study investigates the public acceptance of hydrogen technologies in the United Kingdom's domestic energy sector, with a focus on green and low‐carbon hydrogen as a pathway to decarbonisation.
Nikhil Ahlawat, Ravi Kumar Pandit
doaj +1 more source
Thesis on Firm Life Cycle, Product Life Cycle, and Retail Life Cycle
Management (Split), 1997 In this paper, the conceptions on firm life cycle, product life cycle and retail life cycle (institution and shop) have been analyzed. Conceptions based on biology have been compared as well. In retail forms specific qualities of particular approaches are described, connected with the efforts of a firm on that development, using price and other ...
openaire +1 more source