Results 71 to 80 of about 1,623,376 (313)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
SSRN Electronic JournalThis paper explores the evolution of occupations within the context of industry and technology life cycles, highlighting the critical yet underexplored intersection between occupational trends and broader economic dynamics. Introducing the Occupation Life Cycle (OLC) model, we delineate five stages (i.e., growth, peak, fluctuation, maturity, and ...
Lan Chen +3 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Value-oriented decision support for design to life cycle
, 2022 5 S.The design of industrial products considering their entire life cycle must satisfy technical and ecological requirements while providing maximum economic benefit. During the early stages of design and development decisions about the product functions
Westkämper, Engelbert, Janz, Danina
core
Review of Life Cycle Assessment in Agro-Chemical Processes [PDF]
, 2010 Life Cycle Assessment (LCA) is a method used to evaluate the potential impacts on the environment of a product, process, or activity throughout its life cycle.
Sayed Tamizuddin Gillani +12 more
core +1 more source
The Life Cycle of Sporocytophaga [PDF]
Journal of General Microbiology, 1951 SUMMARY: The life cycle in Sporocytophaga closely resembles that of the non-sporing eubacteria. The haploid microcyst germinates, the resulting cell containing two paired chromosomes reproducing vegetatively. An autogamous fusion and subsequent reduction division precede the maturation of the microcyst.
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Life Cycle in Startup Valuation
, 2023 The business valuation process begins with the projection of the company’s sales or income, so it is important to establish how they will evolve over time.
Bravo Orellana, Sergio Rafael
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source