Results 81 to 90 of about 4,110,851 (310)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Life cycle analysis of road construction and use [PDF]
, 2019 Both the construction and use of roads have a range of environmental impacts; therefore, it is important to assess the sources of their burdens to adopt correct mitigation policies.
D'Andrea, Antonio +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
IEEE Access, 2018 An electrostatic discharge (ESD) event can cause a medical device to fail and pose a threat to patients'safety. This paper presents the data mining analysis of ESD failures in medical devices, over the last ten years, using the U.S.
Mehdi Kohani, Michael Pecht
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Thesis on Firm Life Cycle, Product Life Cycle, and Retail Life Cycle
Management (Split), 1997 In this paper, the conceptions on firm life cycle, product life cycle and retail life cycle (institution and shop) have been analyzed. Conceptions based on biology have been compared as well. In retail forms specific qualities of particular approaches are described, connected with the efforts of a firm on that development, using price and other ...
openaire +1 more source
Sustainability index analysis for environmentally low-input integrated farming [PDF]
Global Journal of Environmental Science and ManagementBACKGROUND AND OBJECTIVES: Integrated farming is an efficient and environmentally friendly agricultural activity that uses low-input resources, including abundant local materials, such as waste.
E. Widjaja +19 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Energy Science & EngineeringThis study investigates the public acceptance of hydrogen technologies in the United Kingdom's domestic energy sector, with a focus on green and low‐carbon hydrogen as a pathway to decarbonisation.
Nikhil Ahlawat, Ravi Kumar Pandit
doaj +1 more source
Analyzing labour supply of elderly people: a life-cycle approach [PDF]
In light of the ageing of the Dutch society, policy measures aim at increasing the participation rate of elderly workers, particularly in the age-group between 55 and 64. This paper develops a stylized numerical simulation model.
Frank van Erp, Paul de Hek
core