Results 61 to 70 of about 9,341,349 (251)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
grjacobs/mfsr-life-cycle: MFSR life-cycle v1.0.0
, 2023 This repository contains a JAGS program that fits a Bayesian state-space model of the Chinook salmon life cycle. Methods used to fit this model to Snake River spring/summer Chinook salmon from the Middle Fork Salmon River, Idaho, USA, are included in a ...
Greg Jacobs
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Cleaner Environmental SystemsMaterial losses in hard-gold plating during rinsing are a costly aspect of printed circuit board (PCB) production and lead to environmental impacts from raw materials that do not end up in the final products. Previously, washing water containing gold was
Ehsan Nemati +6 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
IEEE Access, 2020 This paper analyzes artificial intelligence (AI)-related patents that were granted by the U.S. Patent and Trademark Office (USPTO) between January 2008 and December 2018.
Hamidreza Habibollahi Najaf Abadi +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Flood Risk ManagementUrban stormwater waterlogging poses significant threats to public safety and property, making scientific and effective risk management a crucial element in China's whole‐area sponge city construction.
Yang Yun‐chuan +7 more
doaj +1 more source