Results 51 to 60 of about 462,001 (256)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Buffalo rumen microbial cellulase as a candidate enzyme for hydrolysis of rice straw into glucose: A preliminary study

Open Veterinary Journal
Background: The buffalo rumen microbiome is enriched in functional genes, notably those encoding betaglucosidase which participate in polysaccharide breakdown.
Agung Prabowo, Slamet Hartanto, Dini Dwi Ludfiani, Bambang Haryanto, Miranti Dian Pertiwi, Abd. Azis Wasil, Maya Larasati Donna Wardani, Nandari Dyah Suretno, Rini Nur Hayati, Forita Dyah Arianti, Arif Dwi Santoso, Megawati Megawati, Widi Astuti, Nuruliarizki Shinta Pandupuspitasari, Asih Kurniawati, Zaenal Bachruddin   +15 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ensiling treatment of rice straw with cow paunch content to enhance bioethanol production

Case Studies in Chemical and Environmental Engineering
Every year, the production of rice straw and cow paunch content is abundant and 80 % of them has not been utilized. This study aimed to determine the potency of ensiling treatment on them in producing bioethanol.
Dini Dwi Ludfiani, Forita Dyah Arianti, Miranti Dian Pertiwi, Teguh Prasetyo, Ira Nurhayati Djarot, Arif Dwi Santoso, Nugroho Adi Sasongko, Widi Astuti   +7 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Land use planning strategies for food versus non-food estate sustainable farming [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Food estate initiative is an Indonesian government program designed to achieve food security though the cultivation of strategic commodities on large-scale agricultural land. Despite being controversial due to the scale of land
D. Juhandi, D.H. Darwanto, M. Masyhuri, J.H. Mulyo, N.A. Sasongko, H.L. Susilawati, A. Meilin, T. Martini   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source