Results 81 to 90 of about 1,910,644 (290)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Exploring the potential of water hyacinth weed (Pontederia crassipes) as an environmentally friendly antifungal to realize sustainable development in lakes: A review

Case Studies in Chemical and Environmental Engineering
Pontederia crassipes is an invasive plant in all aquatic environment, especially in stagnant water such as lakes. This plant contains bioactive compounds with environmentally friendly antifungal properties.
Rita Dwi Ratnani, Forita Dyah Arianti, Nugroho Adi Sasongko   +2 more
doaj   +1 more source

Comparative life cycle assessment of current and future electricity generation systems in the Czech Republic and Poland [PDF]

, 2018
Purpose The purpose of the study was to perform a comparative life cycle assessment of current and future electricity generation systems in the Czech Republic and Poland.
Blaut, Agata, Burchart-Korol, Dorota, Jursová, Simona, Korol, Jerzy, Pustějovská, Pavlína   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Evaluating the impacts of environmental and human health of the critical minerals mining and processing industries in Indonesia using life cycle assessment

Case Studies in Chemical and Environmental Engineering
The critical minerals industries in Indonesia may pose possible environmental and human health risks due to the release of pollutants into soil, water, and air, as well as the use of materials and energy.
Yoyon Wahyono, Nugroho Adi Sasongko, Allan Trench, Martin Anda, Hadiyanto Hadiyanto, Nyayu Aisyah, Anisah Anisah, Novy Ariyanto, Isnaeni Kumalasari, Virny Zasyana Eka Putri, Mutia Citrawati Lestari, Lambas Parlaungan Panggabean, Rohmadi Ridlo, Sundari Sundari, Anissa Dewi Suryaningtyas, Endah Dwi Novianti, Muhammad Raihan Farras Hakim, Anggara Lomak Prihatin, Hashfi Hawali Abdul Matin   +18 more
doaj   +1 more source

Life Cycle Assessment (LCA) Comparing Disinfection Options for Drinking Water Treatment [PDF]

, 2018
Drinking water treatment is essential to obtain a healthy source of water that can be distributed throughout a community. There are various methods to disinfect water, and all have trade-offs regarding public health and the environment.
Hidrovo, Alexandria
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source