Results 61 to 70 of about 2,415,273 (347)

The Implementation Factors of Information and Communication Technology in the Life Cycle Costs of Buildings

open access: yesApplied Sciences, 2021
Life cycle cost management is an integral part of buildings construction. The life cycle cost approach can be considered an objective approach because it considers all life cycles of buildings.
Peter Mésároš   +4 more
doaj   +1 more source

Development of a whole life cycle cost model for electrification options on the UK rail system [PDF]

open access: yes, 2016
Projects to deliver Overhead Line Equipment (OLE) electrification on the UK rail infrastructure system presents technical challenges which the rail industry in Britain have not traditionally had to consider.
Baguley, Paul   +2 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Stock Market Participation, Portfolio Choice and Pensions over the Life-cycle [PDF]

open access: yes, 2007
In this paper we present a calibrated life-cycle model is able to simultaneously match asset allocations and stock market participation profiles over the life-cycle.
Ball, Steffan
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Life-Cycle Cost Analysis in Pavement Management System

open access: yesCommunications, 2013
Pavement Management System (PMS) is a set of methods and tools which allow for optimal allocation of limited resources while keeping the road network in serviceable condition.
Jan Mikolaj   +2 more
doaj   +1 more source

Monte Carlo simulation by computer for life-cycle costing [PDF]

open access: yes, 1969
Prediction of behavior and support requirements during the entire life cycle of a system enables accurate cost estimates by using the Monte Carlo simulation by computer.
Gralow, F. H., Larson, W. J.
core   +1 more source

BIM-VE-Based Optimization of Green Building Envelope from the Perspective of both Energy Saving and Life Cycle Cost

open access: yesSustainability, 2020
In the context of the increasingly severe energy crisis and global warming, green buildings and their energy-saving issues are being paid more attention in the world.
Zhenmin Yuan   +5 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

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