Results 71 to 80 of about 11,136,740 (275)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Whole of life cycle cost analysis in bridge rehabilitation [PDF]

, 2002
The report presents a methodology for whole of life cycle cost analysis of alternative treatment options for bridge structures, which require rehabilitation.

core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Cost engineering for manufacturing: current and future research [PDF]

, 2011
This paper aims to review the current practice in cost engineering, identify the scientific research challenges and suggest future direction of this area research.
E. Shehab (7211669), Cheung, Wai Ming, Erkoyuncu, J. A., Newnes, Linda, Roy, R.,, Wang, Qing, Shehab, E., Baguley, P.,, P. Arundachawat (7211666), P. Baguley, J.A. Erkoyuncu (7211654), F. Elgh (7211651), Shehab, E.,, Wang, Q., Erkoyuncu, John Ahmed, Q. Wang, Cheung, W. M., Xu, Y., Q. Wang (782488), Roy, R., Yee Goh (1256379), Baguley, P., Goh, Yee Mey, Arundachawat, P.,, F. Elgh, Goh, Y.,, Elgh, Fredrik,, Bankole, O.,, R. Roy, Newnes, L.,, Baguley, Paul, Y. Goh, Shehab, Essam, Cheung, W. M.,, E. Shehab, O. Bankole (7211657), Newnes, L., Cheung, W.M., Y. Xu (741407), Erkoyuncu, J.A., Y. Xu, Roy, Rajkumar, O. Bankole, Wang, Q.,, J. A. Erkoyuncu, Goh, Y., R. Roy (2538628), Elgh, F., Arundachawat, Panumas, Bankole, O., Xu, Yuchun,, Linda B. Newnes (7204940), W. M. Cheung, P. Baguley (7211663), Erkoyuncu, John,, Xu, Yuchun, Bankole, Oyetola, L. Newnes, P. Arundachawat, Arundachawat, P., W.M. Cheung (7211660)   +60 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A Comprehensive Review on Construction Applications and Life Cycle Sustainability of Natural Fiber Biocomposites

, 2022
The construction industry is continuously searching for sustainable materials to combat the rapid depletion of global resources and ongoing ecological crises.
Rehan Sadiq, Hammad Ahmad, Hewage, Kasun, Chhipi-Shrestha, Gyan, Sadiq, Rehan, Ahmad, Hammad, Gyan Chhipi-Shrestha, Kasun Hewage   +7 more
core   +1 more source

Customer life cycle cost accounting – conceptual assumptions for State Forests [PDF]

Zeszyty Teoretyczne Rachunkowości
Purpose: The main objective of the article is to establish the conceptual assumptions of customer life cycle cost accounting in light of the results of research and the operational context of the State Forests (Lasy Państwowe – LP).
Piotr Szczypa, Grzegorz Lew
doaj   +1 more source