Results 61 to 70 of about 305,477 (300)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Research on Highway Maintenance and Management Cost Based on Life Cycle Cost Analysis [PDF]
E3S Web of ConferencesWith the rapid development of China’s highway construction, the huge demand for funds and the lack of financial strength of the contradiction is increasingly obvious, can effectively control the maintenance costs, highway operators to obtain sustainable ...
Li Jiarong, Gou Lijuan, Men Feng
doaj +1 more source
Environmentally conscious design : an economic life cycle approach [PDF]
, 1997 Companies are under increasing pressure to deal with environmental concerns during product design, for it is the design process which primarily decides the environmental impact of a manufactured product over its life.
Rose, Elliot P., Rose, E.P.
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
An extended life cycle analysis of packaging systems for fruit and vegetable transport in Europe
, 2022 S.1549-1567Purpose: The year-round supply of fresh fruit and vegetables in Europe requires a complex logistics system. In this study, the most common European fruit and vegetable transport packaging systems, namely single-use wooden and cardboard boxes ...
Albrecht, Stefan +8 more
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Life cycle cost estimation tool for decision-making in the early phases of the design process [PDF]
, 2007 Design is a process that involves information processing and decision-making. As cost is an important factor that must be considered in the decision-making at this phase, proper information about costs is extremely important for designers.
Dimache, Aurora +3 more
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