Results 91 to 100 of about 1,949,985 (343)

Does OO sync with the way we think? [PDF]

open access: yes, 1998
Given that corrective-maintenance costs already dominate the software life cycle and look set to increase significantly, reliability in the form of reducing such costs should be the most important software improvement goal.
Hatton, Leslie
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

LIFE-CYCLE COST AS AN ASSESSMENT OF THE FINANCIAL EFFECTIVENESS OF AN INVESTMENT AND CONSTRUCTION PROJECT OF SOCIAL INFRASTRUCTURE

open access: yesВестник университета, 2020
Original approach to assessment and evaluation of financial effectiveness of an investment project in state area via the life-cycle cost has been proposed.
A. A. Kuznetsov
doaj   +1 more source

Simplified Estimation of Seismic Life-Cycle Costs [PDF]

open access: yes, 2004
Most seismic risk assessments for economic decision-making of commercial buildings are based on a risk metric called probable maximum loss (PML) that is associated with losses from an earthquake shaking severity with a 500-year return period.
Beck, James L.   +2 more
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

A normative price for energy from an electricity generation system: An Owner-dependent Methodology for Energy Generation (system) Assessment (OMEGA). Volume 2: Derivation of system energy price equations [PDF]

open access: yes
The methodology presented is a derivation of the utility owned solar electric systems model. The net present value of the system is determined by consideration of all financial benefits and costs including a specified return on investment.
Chamberlain, R. G., Mcmaster, K. M.
core   +1 more source

A multi-objective framework for the optimisation of life-cycle costs of wind turbines [PDF]

open access: yes, 2016
Peer reviewedPublisher ...
Hanish Nithin, Anu, Omenzetter, Piotr
core  

The use of non-intrusive user logging to capture engineering rationale, knowledge and intent during the product life cycle [PDF]

open access: yes, 2008
Within the context of Life Cycle Engineering it is important that structured engineering information and knowledge are captured at all phases of the product life cycle for future reference.
Corney, Jonathan R.   +5 more
core   +1 more source

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