Results 91 to 100 of about 195,446 (304)

The LIFE project research review: mapping the landscape, riding a life cycle

open access: yes, 2005
The LIFE project research review investigates both life cycle costing and digital preservation, with a view to creating a useable life cycle costing model that can be applied to digital preservation within an HE/FE environment.
Watson, J.
core  

A framework for documenting and analyzing life-cycle costs using a simple network based representation [PDF]

open access: yes, 2003
The introduction of high reliability systems combined with new ways of operating complex systems, particularly in aircraft design and operation has received much attention in recent years.
Davis, Neil D.   +2 more
core  

Obtaining life-cycle cost-effective facilities in the Department of Defense /

open access: yes, 2013
The Department of Defense (DoD) constructs, operates, and maintains a large number of facilities, such as barracks, hangars, and administrative buildings.
Samaras, Constantine.   +3 more
core   +1 more source

Buildings’ Life Cycle Environmental Impacts and Costs Assessment

open access: yes
This article presents an buildings life cycle environmental impact assessment and related costs that is applicable to construction phases. Life cycle analysis is considered the best tool because it examines the full range of impacts over all the phases ...
Tambovceva, Tatjana
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

How family status and social security claiming options shape optimal life cycle portfolios : [Version October 20, 2013] [PDF]

open access: yes, 2013
Household decisions are profoundly shaped by a complex set of financial options due to Social Security rules determining retirement, spousal, and survivor benefits, along with benefit adjustments that vary with the age at which these are claimed.
Raimond Maurer   +6 more
core   +1 more source

Energy Retrofitting of a Buildings’ Envelope: Assessment of the Environmental, Economic and Energy (3E) Performance of a Cork-Based Thermal Insulating Rendering Mortar

open access: yesEnergies, 2019
This paper presents an environmental, economic and energy (3E) assessment of an energy retrofitting of the external walls of a flat of an average building with the most current characteristics used in Portugal.
José D. Silvestre   +4 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Life cycle cost estimation tool for decision-making in the early phases of the design process [PDF]

open access: yes, 2007
Design is a process that involves information processing and decision-making. As cost is an important factor that must be considered in the decision-making at this phase, proper information about costs is extremely important for designers.
Dimache, Aurora   +3 more
core  

Proposal of a closed loop framework for the improvement of industrial systems' life cycle performances: Experiences from the linked design project [PDF]

open access: yes, 2015
VK: Främling, K.The context where European manufacturers of industrial systems operate has dramatically changed over recent years: the pressure of emerging countries they have to face, policy makers’ environmental laws and industrial companies’ interests
Kiritsis, Dimitris   +9 more
core   +1 more source

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