Results 71 to 80 of about 1,949,985 (343)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Modelling of life cycle cost of conventional and alternative vehicles

open access: yesScientific Reports, 2022
Over the past decade, the passenger transport segment has undergone significant changes, particularly in the way vehicles are propelled. These changes have been influenced by the global drive to reduce the environmental burden associated with the ...
Jan Furch   +2 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

EVALUATING THE LIFE CYCLE COSTS OF PLANT ASSETS – A MULTIDIMENSIONAL VIEW [PDF]

open access: yesSerbian Journal of Management, 2012
This paper shows the results of the task group "Asset life cycle management" of the AustrianScientific Maintenance and Asset Management Association (ÖVIA).
Markus Gram, Werner E. Schroeder
doaj  

Proposed method for estimating the costs of safety barrier life cycle

open access: yesMATEC Web of Conferences, 2018
Today barrier types are frequently selected for their price with little regard for the total costs the structure will incur over its lifetime. One of the basic tools designed to manage road infrastructure is the life cycle cost method (LCC, Life cycle ...
Jamroz Kazimierz   +3 more
doaj   +1 more source

Life Cycle Costs & Housing Affordability Measurement [PDF]

open access: yes, 2010
This paper examines current problems with home ownership affordability measurement and presents an innovative affordability measurement model that incorporates a comprehensive assessment and risk analysis of housing life cycle costs. The main method used
Smith, PV
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Entry Costs and Stock Market Participation Over the Life Cycle [PDF]

open access: yes
Several explanations for the observed limited stock market participation have been offered in the literature. One of the most promising one is the presence of market frictions mostly in the form of fixed entry and/or transaction costs.
Sule Alan
core   +3 more sources

Time is money: life cycle rational inertia and delegation of investment management : [Version November 2013] [PDF]

open access: yes, 2013
We investigate the theoretical impact of including two empirically-grounded insights in a dynamic life cycle portfolio choice model. The first is to recognize that, when managing their own financial wealth, investors incur opportunity costs in terms of ...
Kim, Hugh H.   +2 more
core  

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