Results 71 to 80 of about 195,446 (304)

Life cycle management of natural infrastructure: assessment of state of practice and current tools

open access: yesFrontiers in Built Environment
Design alternatives for traditional infrastructure are often compared in terms of expected–and often narrowly defined–costs and benefits to justify the selected plan.
Margaret H. Kurth   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Development of a life cycle cost estimating framework for oil refineries [PDF]

open access: yes, 2011
This study is concerned with the understanding of some vital features of various life cycle costing methodologies and tools. Integrating these features with the refinery technical processes would assist in the development of a life cycle costing ...
Okafor, Okechukwu Peter
core  

Achieving a holistic view of the life cycle performance of existing dwellings

open access: yes, 2013
Models which fully evaluate the life cycle energy and greenhouse gas (GHG) emissions of national housing stocks are not reported in literature. Capturing a holistic view of energy and emissions of the residential sector is an important process that can ...
Duffy, Aidan   +4 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Life Cycle Models of Buildings - a New Approach

open access: yes, 1997
The idea of life cycle cost was developed a quarter of a century ago. A wide dissemination of the term was given through a report for the US Secretary of Defense “Life Cycle Cost in Equipment Procuration”.
B. Barth   +7 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Time is money: life cycle rational inertia and delegation of investment management : [Version November 2013]

open access: yes, 2013
We investigate the theoretical impact of including two empirically-grounded insights in a dynamic life cycle portfolio choice model. The first is to recognize that, when managing their own financial wealth, investors incur opportunity costs in terms of ...
Mitchell, Olivia S.   +2 more
core  

Proposal of a Model for Life Cycle Optimization of Industrial Equipment [PDF]

open access: yes, 2014
Pressure of emergent countries, policy makers and industrial companies’ interests are pushing European companies towards a high consideration of whole product life cycle.
TERZI, Sergio
core   +1 more source

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