Results 101 to 110 of about 1,232,833 (305)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Laser-based selective killing of a manipulative parasite reveals partial reversibility of phenotypic alterations in its intermediate host

Current Research in Parasitology and Vector-Borne Diseases
Various parasites alter their intermediate hostʼs phenotype in ways that increase parasite transmission to definitive hosts. To what extent infected intermediate hosts can recover from such “manipulation” is poorly documented, thus limiting our ...
Marie-Jeanne Perrot-Minnot, Frank Cézilly, Olivier Musset   +2 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

The Life Cycle Model of Consumption and Saving [PDF]

The life-cycle model is the standard framework which economists use to think about the intertemporal allocation of time, money and effort. The model suggests that households should `smooth' expenditures.
Martin Browning, Thomas F. Crossley
core  

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Life Cycle Cost Analysis and Deterioration Patterns of Limestone Paving

Applied Sciences
Stone is a durable and high-performance paving material in standard and in intensive service regimes. Stone is thus a preferable material for sidewalk and promenade paving under intensive service regimes, such as touristic promenades and historic sites ...
Irena (Rina) Wasserman, Igal M. Shohet
doaj   +1 more source

Orbiting deep space relay station. Volume 3: Implementation plan [PDF]

An implementation plan for the Orbiting Deep Space Relay Station (ODSRS) is described. A comparison of ODSRS life cycle costs to other configuration options meeting future communication requirements is ...
Hunter, J. A.
core   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

From short-term profitability to long-term sustainability: exploring life cycle cost in chemical processes

Cleaner Environmental Systems
As industries increasingly adopt sustainability-oriented strategies, economic assessment methods should evolve to incorporate environmental externalities and long-term system impacts.
Yuree Kwon, Yongchul Jang, Jinjoo An
doaj   +1 more source

LIFE3: A predictive costing tool for digital collections [PDF]

, 2010
Predicting the costs of long-term digital preservation is a crucial yet complex task for even the largest repositories and institutions. For smaller projects and individual researchers faced with preservation requirements, the problem is even more ...
Hole, B., Lin, L., McCann, P., Wheatley, P.   +3 more
core