Results 111 to 120 of about 10,765,901 (291)

Hydrothermal Processing of Microorganisms: Mass Spectral Signals of Degraded Biosignatures for Life Detection on Icy Moons. [PDF]

ACS Earth Space Chem, 2022
Salter TL, Watson JS, Waite JH, Sephton MA.   +3 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Life Detection and Microbial Biomarker Profiling with Signs of Life Detector-Life Detector Chip During a Mars Drilling Simulation Campaign in the Hyperarid Core of the Atacama Desert. [PDF]

Astrobiology, 2023
Moreno-Paz M, Dos Santos Severino RS, Sánchez-García L, Manchado JM, García-Villadangos M, Aguirre J, Fernández-Martínez MA, Carrizo D, Kobayashi L, Dave A, Warren-Rhodes K, Davila A, Stoker CR, Glass B, Parro V.   +14 more
europepmc   +1 more source

Functional Study of SAMD9L in Familial Gastric Cancer

The Turkish Journal of Gastroenterology, 2023
Xu Kaixuan, Zhang Xiaobin, Tang Jiaxuan, Liu Shihui , Wang Xinxin, Hu Shuwei , Dai Penggao, Luo Xiang   +7 more
doaj   +1 more source

Can AI Detect Life? Lessons from Artificial Life

CoRR
Modern machine learning methods have been proposed to detect life in extraterrestrial samples, drawing on their ability to distinguish biotic from abiotic samples based on training models using natural and synthetic organic molecular mixtures. Here we show using Artificial Life that such methods are easily fooled into detecting life with near 100 ...
Ankit Gupta, Christoph Adami
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Imaging technologies and strategies for detection of extant extraterrestrial microorganisms

Advances in Physics: X, 2018
There is no reductionist definition of life, so the way organisms look, behave, and move is the most definitive way to identify extraterrestrial life.
Jay L. Nadeau, Manuel Bedrossian, Christian A. Lindensmith   +2 more
doaj   +1 more source

Life.

, 1883
Microfilm.Mode of access: Internet.Discontinued as a humorous publication.

core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Ground-Based BIOMEX Experiment Verification Tests for Life Detection on Mars. [PDF]

Life (Basel), 2021
Pacelli C, Cassaro A, Catanzaro I, Baqué M, Maturilli A, Böttger U, Rabbow E, de Vera JP, Onofri S.   +8 more
europepmc   +1 more source