Results 91 to 100 of about 1,495,502 (258)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Life Detection and Microbial Biomarker Profiling with Signs of Life Detector-Life Detector Chip During a Mars Drilling Simulation Campaign in the Hyperarid Core of the Atacama Desert. [PDF]

Astrobiology, 2023
Moreno-Paz M, Dos Santos Severino RS, Sánchez-García L, Manchado JM, García-Villadangos M, Aguirre J, Fernández-Martínez MA, Carrizo D, Kobayashi L, Dave A, Warren-Rhodes K, Davila A, Stoker CR, Glass B, Parro V.   +14 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Hydrothermal Processing of Microorganisms: Mass Spectral Signals of Degraded Biosignatures for Life Detection on Icy Moons. [PDF]

ACS Earth Space Chem, 2022
Salter TL, Watson JS, Waite JH, Sephton MA.   +3 more
europepmc   +1 more source

Can AI Detect Life? Lessons from Artificial Life

CoRR
6 pages, 7 figures.
Ankit Gupta, Christoph Adami
openaire   +2 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Functional Study of SAMD9L in Familial Gastric Cancer

The Turkish Journal of Gastroenterology, 2023
Xu Kaixuan, Zhang Xiaobin, Tang Jiaxuan, Liu Shihui , Wang Xinxin, Hu Shuwei , Dai Penggao, Luo Xiang   +7 more
doaj   +1 more source

Understanding biological motion through the lens of animate motion processing

Frontiers in Psychology
Biological motion (BM), the movement generated by living entities, transmits signals of life and conveys vital cues for animacy perception. In this review, we synthesize empirical findings from human and non-human animal studies to reveal how BM enjoys a
Li Shen, Li Shen, Xinlin Yang, Xinlin Yang, Yi Jiang, Yi Jiang, Ying Wang, Ying Wang   +7 more
doaj   +1 more source

The Ground-Based BIOMEX Experiment Verification Tests for Life Detection on Mars. [PDF]

Life (Basel), 2021
Pacelli C, Cassaro A, Catanzaro I, Baqué M, Maturilli A, Böttger U, Rabbow E, de Vera JP, Onofri S.   +8 more
europepmc   +1 more source