Results 81 to 90 of about 10,765,901 (291)

Determination of Geochemical Bio-Signatures in Mars-Like Basaltic Environments

Frontiers in Microbiology, 2017
Bio-signatures play a central role in determining whether life existed on early Mars. Using a terrestrial basalt as a compositional analog for the martian surface, we applied a combination of experimental microbiology and thermochemical modeling ...
Karen Olsson-Francis, Victoria K. Pearson, Elisabeth D. Steer, Elisabeth D. Steer, Susanne P. Schwenzer   +4 more
doaj   +1 more source

Groundwork for Life Detection [PDF]

Bulletin of the AAS, 2021
Tori Hoehler, Will Brinckerhoff, Alfonso Davila, David Des Marais, Stephanie Getty, Danny Glavin, Andrew Pohorille, Richard Quinn, Lee Bebout, Jared Broddrick, Christopher Dateo, Jennifer Eigenbrode, Craig Everroad, Fathi Karouia, Barbara Lafuente, Graham Lau, Paul Mahaffy, Marc Neveu, Andro Rios, Sanjoy Som   +19 more
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Canine Olfactory Thresholds to Amyl Acetate in a Biomedical Detection Scenario

Frontiers in Veterinary Science, 2019
Dogs' abilities to respond to concentrations of odorant molecules are generally deemed superior to electronic sensors. This sensitivity has been used traditionally in many areas; but is a more recent innovation within the medical field.
Astrid R. Concha, Astrid R. Concha, Claire M. Guest, Rob Harris, Thomas W. Pike, Alexandre Feugier, Helen Zulch, Helen Zulch, Daniel S. Mills   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

An exploration of origin of life for exoplanetary science

Frontiers in Astronomy and Space Sciences
The factors that enable life to begin define the difference between an inhabited planet and one that is simply habitable. While used extensively in Origins, Worlds, and Life: A Decadal Strategy for Planetary Science and Astrobiology 2023–2032 ...
Finnegan Keller, Tiffany Kataria, Laura M. Barge, Pin Chen, Yuk Yung, Jessica M. Weber   +5 more
doaj   +1 more source

What can the life course approach contribute to an understanding of longevity risk? [PDF]

, 2016
Longevity risk means living longer than predicted. Attempts to understand longevity risk to date have concentrated on single diseases, usually coronary heart disease, and sought explanations in terms of risk factor change and medical innovation.
Blane, David, Liefbroer, Aart C.; id_orcid, Matthews, Katey, Koupil, Ilona, Hayward, Mark D., Liefbroer, Aart C., Mishra, Gita D., Wahl, Hans-Werner, Matthews, Katherine, Wahrendorf, Morten, Wahl, Hans Werner, Koupil, Ilona,, Akinwale, Bola, Landy, Rebecca, Ferreira, Isabel   +14 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The HOMO-LUMO Gap as Discriminator of Biotic from Abiotic Chemistries

Life
Low-molecular-mass organic chemicals are widely discussed as potential indicators of life in extraterrestrial habitats. However, demarcation lines between biotic chemicals and abiotic chemicals have been difficult to define.
Roman Abrosimov, Bernd Moosmann
doaj   +1 more source