Results 81 to 90 of about 1,495,502 (258)

LINC00540 promotes sorafenib resistance and functions as a ceRNA for miR-4677-3p to regulate AKR1C2 in hepatocellular carcinoma

Heliyon
Sorafenib resistance is one of the main causes of poor prognosis in patients with advanced hepatocellular carcinoma (HCC). Long noncoding RNAs (lncRNAs) function as suppressors or oncogenic factors during tumor progression and drug resistance.
Kaixuan Xu, Xinxin Wang, Shuwei Hu, Jiaxuan Tang, Shihui Liu, Hui Chen, Xiaobin Zhang, Penggao Dai   +7 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Development and performance test of UWB radar life detector for mine borehole rescue

Meikuang Anquan
In response to the problem of blocked escape routes and difficulty in determining the location of trapped personnel caused by mining disasters and accidents, based on the principles and characteristics of ultra wideband (UWB) radar life information ...
Xi CHEN, Hu WEN, Yuan HUANG
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Evaluation of a Sensor System for Detecting Humans Trapped under Rubble: A Pilot Study

Sensors, 2018
Rapid localization of injured survivors by rescue teams to prevent death is a major issue. In this paper, a sensor system for human rescue including three different types of sensors, a CO2 sensor, a thermal camera, and a microphone, is proposed.
Di Zhang, Salvatore Sessa, Ritaro Kasai, Sarah Cosentino, Cimarelli Giacomo, Yasuaki Mochida, Hiroya Yamada, Michele Guarnieri, Atsuo Takanishi   +8 more
doaj   +1 more source

Biosignature stability in space enables their use for life detection on Mars. [PDF]

Sci Adv, 2022
Baqué M, Backhaus T, Meeßen J, Hanke F, Böttger U, Ramkissoon N, Olsson-Francis K, Baumgärtner M, Billi D, Cassaro A, de la Torre Noetzel R, Demets R, Edwards H, Ehrenfreund P, Elsaesser A, Foing B, Foucher F, Huwe B, Joshi J, Kozyrovska N, Lasch P, Lee N, Leuko S, Onofri S, Ott S, Pacelli C, Rabbow E, Rothschild L, Schulze-Makuch D, Selbmann L, Serrano P, Szewzyk U, Verseux C, Wagner D, Westall F, Zucconi L, de Vera JP.   +36 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Dark microbiome and extremely low organics in Atacama fossil delta unveil Mars life detection limits. [PDF]

Nat Commun, 2023
Azua-Bustos A, Fairén AG, González-Silva C, Prieto-Ballesteros O, Carrizo D, Sánchez-García L, Parro V, Fernández-Martínez MÁ, Escudero C, Muñoz-Iglesias V, Fernández-Sampedro M, Molina A, Villadangos MG, Moreno-Paz M, Wierzchos J, Ascaso C, Fornaro T, Brucato JR, Poggiali G, Manrique JA, Veneranda M, López-Reyes G, Sanz-Arranz A, Rull F, Ollila AM, Wiens RC, Reyes-Newell A, Clegg SM, Millan M, Johnson SS, McIntosh O, Szopa C, Freissinet C, Sekine Y, Fukushi K, Morida K, Inoue K, Sakuma H, Rampe E.   +38 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Mission Simulating the Search for Life on Mars with Automated Drilling, Sample Handling, and Life Detection Instruments Performed in the Hyperarid Core of the Atacama Desert, Chile. [PDF]

Astrobiology, 2023
Stoker CR, Glass BJ, Stucky TR, Dave AI, Kobayashi LT, Quinn RC, Moreno-Paz M, Sánchez-García L, Mora MF, Kehl F, Parro V, Willis PA, Davila A, Noe Dobrea E, Rask JC, Ricardo D.   +15 more
europepmc   +1 more source