Results 71 to 80 of about 1,495,502 (258)
Determination of Geochemical Bio-Signatures in Mars-Like Basaltic Environments
Frontiers in Microbiology, 2017 Bio-signatures play a central role in determining whether life existed on early Mars. Using a terrestrial basalt as a compositional analog for the martian surface, we applied a combination of experimental microbiology and thermochemical modeling ...
Karen Olsson-Francis +4 more
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Frontiers in Astronomy and Space Sciences, 2020 Unraveling how long life can persist under extreme dryness and what kind of environmental extremes can be faced by dried microorganisms is relevant to understand Mars habitability and to search for life on planets with transient liquid water availability.
Claudia Fagliarone +5 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An exploration of origin of life for exoplanetary science
Frontiers in Astronomy and Space SciencesThe factors that enable life to begin define the difference between an inhabited planet and one that is simply habitable. While used extensively in Origins, Worlds, and Life: A Decadal Strategy for Planetary Science and Astrobiology 2023–2032 ...
Finnegan Keller +5 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The HOMO-LUMO Gap as Discriminator of Biotic from Abiotic Chemistries
LifeLow-molecular-mass organic chemicals are widely discussed as potential indicators of life in extraterrestrial habitats. However, demarcation lines between biotic chemicals and abiotic chemicals have been difficult to define.
Roman Abrosimov, Bernd Moosmann
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Drug Design, Development and TherapyJun Zheng,1,* Qiqi Zou,2,3,* Chuyan Wang,1 Qianqian Yang,2 Jiuyu Ren,2,3 Xiangyue Cao,2 Huijuan Wang,2,3 Hui Gao1 1Department of Anesthesiology, Affiliated Hospital of Yan’an University, Yan’an, Shaanxi, 716000, People’s Republic of China;
Zheng J +7 more
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