Results 71 to 80 of about 10,765,901 (291)

Principal component analysis and perturbation theory–based robust damage detection of multifunctional aircraft structure [PDF]

, 2013
A fundamental problem in structural damage detection is to define an efficient feature to calculate a damage index. Furthermore, due to perturbations from various sources, we also need to define a rigorous threshold whose overtaking indicates the ...
HAJRYA, Rafik, MECHBAL, Nazih
core   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

A Good Life in Later Years: A Co-Produced Research Project [PDF]

, 2017
The ‘A Good Life Project’ evolved as a co-production study looking at quality of life in later years. Funded by the Life Changes Trust, and in partnership with Age Scotland, researchers from the University of Stirling worked hand in hand with
Gibson, Grant, Robertson, Jane, Greasley-Adams, Corinne, McCall, Vikki   +3 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Returning Samples From Enceladus for Life Detection

Frontiers in Astronomy and Space Sciences, 2020
Evidence suggests that Saturn's icy moon Enceladus has a subsurface ocean that sources plumes of water vapor and ice vented to space from its south pole.
Marc Neveu, Marc Neveu, Ariel D. Anbar, Ariel D. Anbar, Alfonso F. Davila, Daniel P. Glavin, Shannon M. MacKenzie, Charity M. Phillips-Lander, Brent Sherwood, Yoshinori Takano, Peter Williams, Hajime Yano   +11 more
doaj   +1 more source

Life Detection Instruments

The American Biology Teacher, 1969
Introduction The field of biology has been confronted recently with the paradox of being the only natural science which has yet to demonstrate that any of its terrestrially based conceptual schemes have any universal significance. The various thoughts, ideas, and principles of present day biology apply to only one kind of life-life on Earth.
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Application of chemotactic behavior for life detection

Frontiers in Astronomy and Space Sciences
One excellent biosignature for the present detection of microbial life on Earth is motility, leading to its growing interest within the astrobiological community as an observable attribute that, if detected during future in situ space missions, could ...
Max Riekeles, Vincent Bruder, Vincent Bruder, Nicholas Adams, Berke Santos, Berke Santos, Dirk Schulze-Makuch, Dirk Schulze-Makuch, Dirk Schulze-Makuch   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source