Results 51 to 60 of about 1,495,502 (258)

Identification of ASF1A and HJURP by global H3–H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma

Scientific Reports
Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis. Abnormal expression of H3–H4 histone chaperones has been identified in many cancers and holds promise as a biomarker for diagnosis and prognosis.
Yongkang Liu, Shihui Liu, Rui Jing, Congcong Li, Yongqi Guo, Zhiye Cai, Pei Xi, Penggao Dai, Lintao Jia, Hongli Zhu, Xiang Zhang   +10 more
doaj   +1 more source

Canine Olfactory Thresholds to Amyl Acetate in a Biomedical Detection Scenario

Frontiers in Veterinary Science, 2019
Dogs' abilities to respond to concentrations of odorant molecules are generally deemed superior to electronic sensors. This sensitivity has been used traditionally in many areas; but is a more recent innovation within the medical field.
Astrid R. Concha, Astrid R. Concha, Claire M. Guest, Rob Harris, Thomas W. Pike, Alexandre Feugier, Helen Zulch, Helen Zulch, Daniel S. Mills   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

PROSPECTS FOR LIFE IN THE SUBGLACIAL LAKE VOSTOK, EAST ANTARCTICA

Лëд и снег, 2015
The objective was to estimate the genuine microbial content of ice samples from refrozen water (accretion ice) from the subglacialLakeVostok(Antarctica) buried beneath the 4-km thick East Antarctic ice sheet as well as surface snow nearby Vostok station.
S. A. Bulat, D. Marie, J.-R. Petit
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Smart Hydrogel Doped by Metal–Organic Frameworks for Renewable Self‐Pumping Enzymatic Reactors

Advanced Science
The construction of high‐performance immobilized enzymes is vastly desired for green biotransformation. Although hydrogels offer significant potential for facilitating biomedical applications of enzymes due to their flexibility, macroscopic ...
Yuxi Zhu, Shenghao Wang, Yueyuan Luo, Linbo Cao, Xiuxiu Guo, Yue Zhang, Mingmin Li, Tie Wang   +7 more
doaj   +1 more source

Life Detection Instruments

The American Biology Teacher, 1969
Introduction The field of biology has been confronted recently with the paradox of being the only natural science which has yet to demonstrate that any of its terrestrially based conceptual schemes have any universal significance. The various thoughts, ideas, and principles of present day biology apply to only one kind of life-life on Earth.
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source