Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A Mission Simulating the Search for Life on Mars with Automated Drilling, Sample Handling, and Life Detection Instruments Performed in the Hyperarid Core of the Atacama Desert, Chile. [PDF]
Astrobiology, 2023 Stoker CR +15 more
europepmc +1 more source
Onboard Science Instrument Autonomy for the Detection of Microscopy Biosignatures on the Ocean Worlds Life Surveyor [PDF]
, 2023 Mark Wronkiewicz +12 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Evaluation of a Fall Alerting System based on a Convolutional Deep Neural Network [PDF]
, 2019 Artículo sobre detección de caídas con redes neuronales profundasOwing to the effects of falls on quality of life of the elderly, automatic fall detection systems (FDS) have become a key research topic in the ambit of telecare.
Casilari-Pérez, Eduardo +2 more
core
Breast, Early Detection Save Life
Journal of Global Oncology, 2018 Background: Breast cancer is the commonest malignancy afflicting Jordanian females; consisting of about 38% of women cancers; based on Jordan cancer registry (JCR) national data. Aim: Established in 2007 the national Jordan breast cancer program (JBCP) with mission to reduce morbidity and mortality from breast cancer and shift the current state of ...
openaire +1 more source
Functional Study of SAMD9L in Familial Gastric Cancer
The Turkish Journal of Gastroenterology, 2023 Xu Kaixuan +7 more
doaj +1 more source
Development and performance test of UWB radar life detector for mine borehole rescue
Meikuang AnquanIn response to the problem of blocked escape routes and difficulty in determining the location of trapped personnel caused by mining disasters and accidents, based on the principles and characteristics of ultra wideband (UWB) radar life information ...
Xi CHEN, Hu WEN, Yuan HUANG
doaj +1 more source
Life Detection and Microbial Biomarker Profiling with Signs of Life Detector-Life Detector Chip During a Mars Drilling Simulation Campaign in the Hyperarid Core of the Atacama Desert. [PDF]
Astrobiology, 2023 Moreno-Paz M +14 more
europepmc +1 more source