Results 131 to 140 of about 6,867,278 (300)
Good for Living? On the Relation between Globalization and Life Expectancy [PDF]
This paper analyzes the relation between three dimensions of globalization (economic, social and political) and life expectancy using a panel of 92 countries over the period 1970-2005.
Nilsson, Therese, Bergh, Andreas
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A model for geographical variation in health and total life expectancy [PDF]
This paper develops a joint approach to life and health expectancy based on 2001 UK Census data for limiting long term illness and general health status, and on registered death occurrences in 2001.
Peter Congdon
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
BMC GeriatricsBackground Although about 10% of the Latin American population is indigenous, ethnic differences in disability-free life expectancy (DFLE) and life expectancy with disability (DLE) are unknown.
Moisés H. Sandoval +2 more
doaj +1 more source
Trends in life expectancy and the macroeconomy in Malawi [PDF]
The purpose of this paper was to study trends in life expectancy in Malawi since independence and offer possible explanations regarding its inter-temporal variations.
Matchaya, Greenwell C
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Lifesaving, lifetimes and lifetables
Demographic Research, 2005 Mortality change roils period rates. In the short term, conventional calculations of age-specific probabilities of death and life expectancy in the period immediately after the change depend on how many lives have been saved.
James W. Vaupel
doaj
The life expectancy gains from pharmaceutical drugs: a critical appraisal of the literature [PDF]
Several studies suggest that, on the basis of life expectancy (LE) regressions, new pharmaceutical drugs are responsible for some of the marked gains in LE observed over the last 50 years. We critically appraise these studies.
Paul Grootendorst +2 more
core