Results 71 to 80 of about 746,403 (347)

On the relationship between period and cohort mortality

open access: yesDemographic Research, 2005
In this paper I explore the formal relationship between period and cohort mortality, focusing on a comparison of measures of mean lifespan. I consider not only the usual measures (life expectancy at birth for time periods and birth cohorts) but also ...
John R. Wilmoth
doaj  

Healthy life gains in South Australia 1999-2008: analysis of a local Burden of Disease series

open access: yesPopulation Health Metrics, 2011
Background The analysis describes trends in the levels and social distribution of total life expectancy and healthy life expectancy in South Australia from 1999 to 2008.
Woollacott Tony   +2 more
doaj   +1 more source

Age-specific contributions to changes in the period and cohort life expectancy [PDF]

open access: yes
Period life expectancy has increased more slowly than its cohort counterpart. This paper explores the differences between life expectancies at a given time (the gap) and the time required for period life expectancy to reach the current level of cohort ...
Robert Schoen, Vladimir Canudas-Romo
core  

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Survival as a Function of Life Expectancy [PDF]

open access: yes
It is well known that life expectancy can be expressed as an integral of the survival curve. The reverse - that the survival function can be expressed as an integral of life expectancy - is also true.force of mortality, life expectancy, life table ...
James W. Vaupel, Maxim Finkelstein
core  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Does living longer mean living healthier? A comprehensive analysis of 204 countries and regions from 1990 to 2019

open access: yesBMC Public Health
Background The data from the WHO showed that life expectancy (LE) and health-adjusted life expectancy (HALE) at global level both increased from 2000 to 2019, while they did not increase at the same rate.
Bo Xiong, Yuxiao Chen, Ning Chen
doaj   +1 more source

Obesity and Trends in Life Expectancy

open access: yesJournal of Obesity, 2012
Background. Increasing levels of obesity over recent decades have been expected to lead to an epidemic of diabetes and a subsequent reduction in life expectancy, but instead all-cause and cardiovascular-specific mortality rates have decreased steadily in
Helen L. Walls   +3 more
doaj   +1 more source

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