Results 81 to 90 of about 6,867,278 (300)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
On the relationship between period and cohort mortality
Demographic Research, 2005 In this paper I explore the formal relationship between period and cohort mortality, focusing on a comparison of measures of mean lifespan. I consider not only the usual measures (life expectancy at birth for time periods and birth cohorts) but also ...
John R. Wilmoth
doaj
BMC Public HealthBackground Life expectancy is a significant result indicator of public health and sustainable development. Therefore, one of the final objectives of all economic and social policies is to increase the life expectancy. In this context, a limited number of
Yilmaz Bayar +3 more
doaj +1 more source
Life Expectancy at Current Rates vs. Current Conditions [PDF]
Life expectancy is overestimated if mortality is declining and underestimated if mortality is increasing. This is the fundamental claim made by Bongaarts and Feeney (2002) in their article "How Long Do We Live?", where they base their claim on arguments ...
James W. Vaupel
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Happiness and sex difference in life expectancy [PDF]
This paper examines the effects of happiness on the sex gap in life expectancy. Utilizing a cross-country data set, it first inspects the reverse effect of the life expectancy gap on happiness and demonstrates that the life expectancy gap negatively ...
Junji Kageyama
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Human Capital Inequality, Life Expectancy and Economic Growth [PDF]
This paper presents a model in which inequality affects per capita income when individuals decide to invest in education taking into account their life expectancy, which depends to a large extent on the human capital of their parents.
Amparo Castello-Climent, Rafael Domenech
core +2 more sources
Disease and Development: The Effect of Life Expectancy on Economic Growth [PDF]
What is the effect of increasing life expectancy on economic growth? To answer this question, we exploit the international epidemiological transition, the wave of international health innovations and improvements that began in the 1940s.
Daron Acemoglu, Simon Johnson
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source