Results 91 to 100 of about 6,867,278 (300)
Shanghai yufang yixueObjectiveTo analyze the trends in life expectancy and cause-eliminated life expectancy of the registered residents in Qingpu District, Shanghai from 2002 to 2021, and to identify the major diseases causing life expectancy loss in the area, so as to ...
HAN Rongrong +6 more
doaj +1 more source
Convergence or divergence of educational disparities in mortality and morbidity? The evolution of life expectancy and health expectancy by educational attainment in Austria in 1981-2006 [PDF]
The continuous increase in life expectancy in developed countries is typically associated with an increase in the number of years in good health, whereas the number of years in bad health rather stagnates.
Johannes Klotz
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
BMC Public HealthBackground The data from the WHO showed that life expectancy (LE) and health-adjusted life expectancy (HALE) at global level both increased from 2000 to 2019, while they did not increase at the same rate.
Bo Xiong, Yuxiao Chen, Ning Chen
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Decomposition analysis of Spanish life expectancy at birth [PDF]
Using data from the Human Mortality Database (HMD), the paper analyzes the increase in the life expectancy of the Spanish population during the three decades, 1970-2001, in order to ascertain which age and sex groups have made the most progress in terms ...
Carl Boe, Rosa Gómez-Redondo
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Age-specific Income Inequality and Life Expectancy: New Evidence [PDF]
Objectives -- The study has two primary goals. First, to test the hypothesis that higher levels of income inequality are related to lower levels of population health with updated data from around year 2000.
Steven G. Prus, Robert L. Brown
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source