Results 81 to 90 of about 263,601 (301)

Changing impact of COVID-19 on life expectancy 2019–2023 and its decomposition: Findings from 27 countries

SSM: Population Health
Background: The World Health Organization declared COVID-19 no longer a global health emergency on 5th May 2023; however, the impact of COVID-19 on life expectancy throughout the pandemic period is not clear.
Guogui Huang, Fei Guo, Lihua Liu, Lucy Taksa, Zhiming Cheng, Massimiliano Tani, Klaus F. Zimmermann, Marika Franklin, S. Sandun Malpriya Silva   +8 more
doaj   +1 more source

Does Physical Activity Increase Life Expectancy? A Review of the Literature

Journal of Aging Research, 2012
Physical activity reduces many major mortality risk factors including arterial hypertension, diabetes mellitus type 2, dyslipidemia, coronary heart disease, stroke, and cancer.
C. D. Reimers, G. Knapp, A. K. Reimers
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Expected Life Expectancy of Life Expectants Due to Covid-19 Phenotypes Reduced to Life Expectancy Cohorts [PDF]

Open Access Journal of Biogeneric Science and Research, 2021
openaire   +1 more source

Inequalities in US Life Expectancy by Area Unemployment Level, 1990–2010

Scientifica, 2016
This study examined the association between unemployment and life expectancy in the United States during 1990–2010. Census-based unemployment rates were linked to US county-level mortality data.
Gopal K. Singh, Mohammad Siahpush
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Life Expectancy and Healthy Life Expectancy in Great Britain 2001

, 2021
Pia Wohland
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Corrigendum to ‘Temporal Change in the Remaining Life Expectancy in People Who Underwent Percutaneous Coronary Intervention’ The American Journal of Cardiology Volume 187, 15 January 2023, Pages 154-161 [PDF]

, 2023
Lan Gao, Dieu Nguyen, Marj Moodie, Angela Brennan, Diem Dinh, Christopher M. Reid, S. Duffy, David Clark, C. Hiew, Ernesto Oqueli, Dion Stub, Andrew E. Ajani   +11 more
openalex   +1 more source